Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers

Dawar, S., Singh, N., Kanwar, R. K., Kennedy, R. L., Veedu, R. N., Zhou, S. F., Krishnakumar, S., Hazra, S., Sasidharan, S., Duan, W. and Kanwar, J. R. 2013, Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers, Drug discovery today, vol. 18, no. 23-24, pp. 1292-1300.

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Title Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers
Author(s) Dawar, S.
Singh, N.
Kanwar, R. K.
Kennedy, R. L.
Veedu, R. N.
Zhou, S. F.
Krishnakumar, S.
Hazra, S.
Sasidharan, S.
Duan, W.
Kanwar, J. R.
Journal name Drug discovery today
Volume number 18
Issue number 23-24
Start page 1292
End page 1300
Total pages 9
Publisher Elsevier
Place of publication London, England
Publication date 2013-12
ISSN 1359-6446
1878-5832
Keyword(s) metastatic spread of cancer
metastatic cancers
chemotherapy
toxic damage
drug resistance
encapsulated drugs
nanodelivery systems
multifunctional nanoparticles
Summary The recurrence and metastatic spread of cancer are major drawbacks in cancer treatment. Although chemotherapy is one of the most effective methods for the treatment of metastatic cancers, it is nonspecific and causes significant toxic damage. The development of drug resistance to chemotherapeutic agents through various mechanisms also limits their therapeutic potential. However, as we discuss here, the use of nanodelivery systems that are a combination of diagnostics and therapeutics (theranostics) is as relatively novel concept in the treatment of cancer. Such systems are likely to improve the therapeutic benefits of encapsulated drugs and can transit to the desired site, maintaining their pharmaceutical properties. The specific targeting of malignant cells using multifunctional nanoparticles exploits theranostics as an improved agent for delivering anticancer drugs and as a new solution for overriding drug resistance.
Language eng
Field of Research 111202 Cancer Diagnosis
100709 Nanomedicine
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30062738

Document type: Journal Article
Collection: School of Medicine
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Created: Wed, 30 Apr 2014, 13:50:20 EST by Rupinder Kanwar

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