You are not logged in.

Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases

Kanwar, J. R., Shankaranarayanan, J. S., Gurudevan, S. and Kanwar, R. K. 2014, Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases, Drug discovery today, vol. 19, no. 9, pp. 1309-1321, doi: 10.1016/j.drudis.2014.02.009.

Attached Files
Name Description MIMEType Size Downloads

Title Aptamer-based therapeutics of the past, present and future: from the perspective of eye-related diseases
Author(s) Kanwar, J. R.
Shankaranarayanan, J. S.
Gurudevan, S.
Kanwar, R. K.
Journal name Drug discovery today
Volume number 19
Issue number 9
Start page 1309
End page 1321
Total pages 13
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-09
ISSN 1359-6446
Keyword(s) molecular dis-regulation
eye-related diseases
aptamers
therapeutic potential
Summary  Aptamers have emerged as a novel and powerful class of biomolecules with an immense untapped potential. The ability to synthesise highly specific aptamers against any molecular target make them a vital cog in the design of effective therapeutics for the future. However, only a minutia of the enormous potential of this dynamic class of molecule has been exploited. Several aptamers have been studied for the treatment of eye-related disorders, and one such strategy has been successful in therapy. This review gives an account of several eye diseases and their regulatory biomolecules where other nucleic acid therapeutics have been attempted with limited success and how aptamers, with their exceptional flexibility to chemical modifications, can overcome those inherent shortcomings.
Language eng
DOI 10.1016/j.drudis.2014.02.009
Field of Research 111303 Vision Science
030302 Nanochemistry and Supramolecular Chemistry
Socio Economic Objective 920107 Hearing, Vision, Speech and Their Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30062763

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in TR Web of Science
Scopus Citation Count Cited 19 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 224 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Wed, 30 Apr 2014, 16:35:04 EST by Rupinder Kanwar

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.