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The mechanisms of Chansu in inducing efficient apoptosis in colon cancer cells

Li, Chun, Hashimi, Saeed M., Cao, Siyu, Mellick, Albert S., Duan, Wei, Good, David and Wei, Ming Q. 2013, The mechanisms of Chansu in inducing efficient apoptosis in colon cancer cells, Evidence-based complementary and alternative medicine, vol. 2013, Article number 849054, pp. 1-11, doi: 10.1155/2013/849054.

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Title The mechanisms of Chansu in inducing efficient apoptosis in colon cancer cells
Author(s) Li, Chun
Hashimi, Saeed M.
Cao, Siyu
Mellick, Albert S.
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Good, David
Wei, Ming Q.
Journal name Evidence-based complementary and alternative medicine
Volume number 2013
Season Article number 849054
Start page 1
End page 11
Total pages 11
Publisher Hindawi Publishing Corporation
Place of publication New York, N. Y.
Publication date 2013
ISSN 1741-427X
1741-4288
Keyword(s) mechanisms
Chansu
cinobufagin (CBF)
cancer cell death
colon cancer
hypoxia-inducing factor-1 alpha subunit (HIF-1α)
Summary Chansu is one of the most widely used traditional Chinese medicines in China, Japan, and other Southeast Asian countries primarily for antipain, anti-inflammation, and recently anticancer. Over 10 recipes and remedies contained Chansu, which are easily available in pharmacies and hospitals, but the mechanisms of action were not clearly articulated. In the present study, Cinobufagin (CBF), the major compound of Chansu, was employed as a surrogate marker to determine its ability in inducing cancer cell death. As expected, CBF has significant cancer-killing capacity for a range of cancers, but such ability differs markedly. Colon and prostate cancers are more sensitive than skin and lung cancers. Interestingly, cancer cells die through apoptotic pathway either being biphasic caspase- 3-dependent (HCT116) or independent (HT29). Multipathway analysis reveals that CBF-induced apoptosis is likely modulated by the hypoxia-inducing factor-1 alpha subunit (HIF-1𝛼) as its inhibition was evident in vitro and in vivo. Taken together, these results demonstrate that CBF is a potent apoptotic inducer with potential for further development as a novel and effective anticancer agent for a range of cancers, especially colon cancer
Language eng
DOI 10.1155/2013/849054
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Hindawi Publishing Corporation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063100

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.