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A comparison of maternal calcium and magnesium levels in pre-eclamptic and normotensive pregnancies: an observational case–control study

Richards, D.G.D, Lindow, S.W., Carrara, H., Knight, R., Haswell, S.J. and van der Spuy, Z.M. 2014, A comparison of maternal calcium and magnesium levels in pre-eclamptic and normotensive pregnancies: an observational case–control study, BJOG : an international journal of obstetrics and gynaecology, vol. 121, no. 3, pp. 327-336, doi: 10.1111/1471-0528.12436.

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Title A comparison of maternal calcium and magnesium levels in pre-eclamptic and normotensive pregnancies: an observational case–control study
Author(s) Richards, D.G.D
Lindow, S.W.
Carrara, H.
Knight, R.
Haswell, S.J.
van der Spuy, Z.M.
Journal name BJOG : an international journal of obstetrics and gynaecology
Volume number 121
Issue number 3
Start page 327
End page 336
Total pages 10
Publisher Wiley
Place of publication London, Eng.
Publication date 2014-02
ISSN 1470-0328
1471-0528
Keyword(s) Calcium
dietary
hair analysis
magnesium
pre-eclampsia
Summary Objective : Supplementing pregnant women at high risk of developing pre-eclampsia with calcium may reduce the incidence of the disease. This study examines differences in serum and hair concentrations of calcium and magnesium between women with pre-eclamptic and normotensive pregnancies.Design : Observational case–control study.Setting : Two teaching hospitals in Cape Town, South Africa.PopulationWomen with pre-eclamptic (N = 96) or normotensive (N = 96) pregnancies, who delivered a single, live infant.MethodsDemographic and current pregnancy details were retrieved from clinical notes. Each participant completed a dietary questionnaire. Venous blood samples were taken from each participant to assess serum calcium and magnesium concentrations. Hair samples were obtained from all participants and calcium and magnesium levels were measured by inductively coupled plasma optical emission spectrometry (ICPOES).Main outcome measureHair and serum calcium and magnesium concentrations were compared between women with pre-eclamptic and normotensive pregnancies.ResultsDiet and socio-economic status in the two groups were similar. There was no significant difference in the hair calcium level between women with pre-eclamptic [1241 parts per million (ppm); range, 331–4654 ppm] and normotensive (1146 ppm; range, 480–4136 ppm) pregnancies (P = 0.5). Hair calcium levels in both groups were not affected by HIV infection.ConclusionWoman with pre-eclampsia showed no difference in chronic calcium status relative to normotensive women. This finding does not support the current belief that the mechanism by which calcium supplementation reduces the risk of developing pre-eclampsia is by correcting a nutritional deficiency.
Language eng
DOI 10.1111/1471-0528.12436
Field of Research 111402 Obstetrics and Gynaecology
Socio Economic Objective 920507 Women's Health
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2014, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063523

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor Research
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