You are not logged in.
Openly accessible

Minimum inhibitory and bacterial concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas Maltophilia

Betts, Jonathan, Murphy, Christine, Kelly, Stephen and Haswell, Stephen 2012, Minimum inhibitory and bacterial concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas Maltophilia, Journal of microbiology, biotechnology and food sciences, vol. 1, no. 5, pp. 1250-1258.

Attached Files
Name Description MIMEType Size Downloads
haswell-miminuminhibitory-2012.pdf Published version application/pdf 511.36KB 128

Title Minimum inhibitory and bacterial concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas Maltophilia
Author(s) Betts, Jonathan
Murphy, Christine
Kelly, Stephen
Haswell, Stephen
Journal name Journal of microbiology, biotechnology and food sciences
Volume number 1
Issue number 5
Start page 1250
End page 1258
Total pages 9
Publisher Slovak University of Agriculture in Nitra
Place of publication Nitra, Slovakia
Publication date 2012-05
ISSN 1338-5178
Keyword(s) Resistance
synergy
antibacterial
polyphenol
theaflavin
epicatechin
quercetin
Summary Stenotrophomonas maltophilia is an important nosocomial pathogen with intrinsic resistance to multiple antibiotics. Previous investigations have shown flavanols from black tea to possess antibacterial activity. This study describes the determination of minimum inhibitory concentrations and minimum bactericidal concentration for theaflavin independently and in formulations with the polyphenols epicatechin and quercetin against nine clinical isolates of Stenotrophomonas maltophilia and the control isolate NCTC 130141 via the microtitre assay. The results demonstrate that theaflavin has strong antibacterial activity and also shows significant synergism with epicatechin and quercetin. The minimum inhibitory concentrations of the isolates range between 200-400 g/mL for theaflavin and 100-200 g/mL for both theaflavin:epicatechin and theaflavin:quercetin combinations. The minimum bactericidal concentrations were discovered to be a 2 fold increase on those of the minimum inhibitory concentrations. The research highlights the potential use of polyphenols for the clinical treatment of highly antibiotic resistant bacteria.
Language eng
Field of Research 060501 Bacteriology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Slovak University of Agriculture in Nitra
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063532

Document type: Journal Article
Collections: Office of the Deputy Vice-Chancellor Research
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 307 Abstract Views, 128 File Downloads  -  Detailed Statistics
Created: Fri, 23 May 2014, 09:38:48 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.