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Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas Maltophilia

Betts, Jonathan W., Murphy, Christine, Kelly, Stephen M. and Haswell, Stephen J. 2012, Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas Maltophilia, Journal of microbiology, biotechnology and food sciences, vol. 2, no. 3, December-January, pp. 1068-1078.

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Title Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas Maltophilia
Author(s) Betts, Jonathan W.
Murphy, Christine
Kelly, Stephen M.
Haswell, Stephen J.
Journal name Journal of microbiology, biotechnology and food sciences
Volume number 2
Issue number 3
Season December-January
Start page 1068
End page 1078
Total pages 11
Publisher Slovak University of Agriculture in Nitra
Place of publication Nitra, Slovakia
Publication date 2012
ISSN 1338-5178
Keyword(s) antibacterial
theaflavin
polyphenol
synergy
checkerboard
Stenotrophomonas maltophilia
Summary Stenotrophomonas maltophilia is an important opportunistic nosocomial pathogen that shows intrinsic resistance to many antibiotics. This often limits treatment options and can cause lengthy hospital stays. Combination treatments are often used to combat resistance and using natural compounds such as polyphenols could give increased treatment options and even the reuse of antibiotics to which high levels of resistance have been observed. A checkerboard assay was used to determine if any synergy exists between ampicillin and the polyphenol theaflavin against 9 clinical isolates and one control isolate (NCTC 13014) of S. maltophilia. It was discovered that significant synergy (P  0.05) does exist between theaflavin and ampicillin, reducing the mean MIC of ampicillin from 12.5-22.9 µg/mL, in liquid culture, to 3.125-6.25 µg/mL. The FIC index was calculated to be 0.22-0.35 confirming synergy. From these results, significant potential for medical applications can be seen and further investigation is recommended.
Language eng
Field of Research 060501 Bacteriology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Slovak University of Agriculture in Nitra
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063533

Document type: Journal Article
Collections: Office of the Deputy Vice-Chancellor Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.