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Estrogen-related receptor γ is an in vivo receptor of bisphenol A

Tohmé, Marie, Prud’homme, Sophie M., Boulahtouf, Abdel, Samarut, Eric, Brunet, Frederic, Bernard, Laure, Bourguet, William, Gibert, Yann, Balaguer, Patrick and Laudet, Vincent 2014, Estrogen-related receptor γ is an in vivo receptor of bisphenol A, FASEB journal, vol. 28, no. 7, pp. 3124-3133, doi: 10.1096/fj.13-240465.

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Title Estrogen-related receptor γ is an in vivo receptor of bisphenol A
Author(s) Tohmé, Marie
Prud’homme, Sophie M.
Boulahtouf, Abdel
Samarut, Eric
Brunet, Frederic
Bernard, Laure
Bourguet, William
Gibert, Yann
Balaguer, Patrick
Laudet, Vincent
Journal name FASEB journal
Volume number 28
Issue number 7
Start page 3124
End page 3133
Total pages 10
Publisher Federation of American Societies for Experimental Biology
Place of publication Bethesda, Md.
Publication date 2014-07
ISSN 0892-6638
Summary Bisphenol A (BPA) is an endocrine disruptor that displays estrogenic activity. Several reports suggest that BPA may have estrogen receptor-independent effects. In zebrafish, 50 μM BPA exposure induces otic vesicle abnormalities, including otolith aggregation. The purpose of this study was to test if BPA action was mediated in vivo during zebrafish development by the orphan nuclear estrogen related receptor (ERR) γ. Combining pharmacological and functional approaches, we demonstrate that the zebrafish ERRγ mediates BPA-induced malformations in otoliths. Using different bisphenol derivatives, we show that different compounds can induce a similar otolith phenotype than BPA and that the binding affinity of these derivatives to the zebrafish ERRγ correlates with their ability to induce otolith malformations. Morpholino knockdown of ERRγ function suppresses the BPA effect on otoliths whereas overexpression of ERRγ led to a BPA-like otolith phenotype. Moreover, a subphenotypical dose of BPA (1 μM) combined with ERRγ overexpression led to a full-dose (50 μM) BPA otolith phenotype. We therefore conclude that ERRγ mediates the otic vesicle phenotype generated by BPA. Our results suggest that the range of pathways perturbed by this compound and its potential harmful effect are larger than expected.—Tohmé, M., Prud’homme, S. M., Boulahtouf, A., Samarut, E., Brunet, F., Bernard, L., Bourguet, W., Gibert, Y., Balaguer, P., Laudet, V. Estrogen-related receptor γ is an in vivo receptor of bisphenol A.
Language eng
DOI 10.1096/fj.13-240465
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collection: School of Medicine
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Created: Fri, 23 May 2014, 09:41:12 EST

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