Investigating retention characteristics of a mixed-mode stationary phase and the enhancement of monolith selectivity for high-performance liquid chromatography Bassanese, Danielle N., Soliven, Arianne, Stevenson, Paul G., Dennis, Gary R., Barnett, Neil W., Shalliker, R. Andrew and Conlan, Xavier A. 2014, Investigating retention characteristics of a mixed-mode stationary phase and the enhancement of monolith selectivity for high-performance liquid chromatography, Journal of separation science, vol. 37, no. 15, pp. 1937-1943, doi: 10.1002/jssc.201400201. Attached Files Name Description MIMEType Size Downloads Title Investigating retention characteristics of a mixed-mode stationary phase and the enhancement of monolith selectivity for high-performance liquid chromatography Author(s) Bassanese, Danielle N. orcid.org/0000-0001-6822-7963 Soliven, Arianne Stevenson, Paul G. orcid.org/0000-0001-6780-6859 Dennis, Gary R. Barnett, Neil W. Shalliker, R. Andrew Conlan, Xavier A. orcid.org/0000-0003-0829-0551 Journal name Journal of separation science Volume number 37 Issue number 15 Start page 1937 End page 1943 Total pages 7 Publisher Wiley Place of publication Weinheim, Germany Publication date 2014-08 ISSN 1615-9306 1615-9314 Keyword(s) aromatic selectivity cyano columns methylene selectivity mixed-mode columns phenyl columns Summary The synthesis and chromatographic behavior of an analytical size mixed-mode bonded silica monolith was investigated. The monolith was functionalized by an in situ modification process of a bare silica rod with chloro(3-cyanopropyl)dimethyl silane and chlorodimethyl propyl phenyl silane solutions. These ligands were selected in order to combine both resonance and nonresonance π-type bonding within a single separation environment. Selectivity studies were undertaken using n-alkyl benzenes and polycyclic aromatic hydrocarbons in aqueous methanol and acetonitrile mobile phases to assess the methylene and aromatic selectivities of the column. The results fit with the linear solvent strength theory suggesting excellent selectivity of the column was achieved. Comparison studies were performed on monolithic columns that were functionalized separately with cyano and phenyl ligands, suggesting highly conjugated molecules were able to successfully exploit both of the π-type selectivities afforded by the two different ligands on the mixed-mode column. Language eng DOI 10.1002/jssc.201400201 Field of Research 030108 Separation Science Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2014, Wiley Persistent URL http://hdl.handle.net/10536/DRO/DU:30063653 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 28 May 2014, 09:09:45 EST Tue, 24 Jun 2014, 14:08:48 EST Tue, 24 Jun 2014, 15:02:53 EST Wed, 25 Jun 2014, 11:29:25 EST Wed, 25 Jun 2014, 12:56:05 EST Thu, 26 Jun 2014, 08:47:00 EST Fri, 27 Jun 2014, 15:54:25 EST Wed, 13 Aug 2014, 12:28:21 EST Wed, 13 Aug 2014, 12:29:29 EST Fri, 22 Aug 2014, 16:32:57 EST Thu, 28 Aug 2014, 07:42:13 EST Mon, 19 Jan 2015, 12:25:12 EST Fri, 06 Feb 2015, 11:28:25 EST Fri, 09 Oct 2015, 17:07:45 EST Mon, 12 Oct 2015, 15:29:39 EST Wed, 14 Oct 2015, 13:46:53 EST Mon, 23 Nov 2015, 09:49:39 EST Filtered Full Citation counts:   Cited 9 times in TR Web of Science Cited 9 times in Scopus Search Google Scholar Access Statistics: 627 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Wed, 28 May 2014, 09:09:17 EST by Paul Stevenson

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