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Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours

Ujvari, Beata, Pearse, Anne-Maree, Swift, Kate, Hodson, Pamela, Hua, Bobby, Pyecroft, Stephen, Taylor, Robyn, Hamede, Rodrigo, Jones, Menna, Belov, Katherine Belov and Madsen, Thomas 2014, Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours, Evolutionary applications, vol. 7, no. 2 (FEBRUARY), pp. 260-265, doi: 10.1111/eva.12117.

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Title Anthropogenic selection enhances cancer evolution in Tasmanian devil tumours
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata
Pearse, Anne-Maree
Swift, Kate
Hodson, Pamela
Hua, Bobby
Pyecroft, Stephen
Taylor, Robyn
Hamede, Rodrigo
Jones, Menna
Belov, Katherine Belov
Madsen, Thomas
Journal name Evolutionary applications
Volume number 7
Issue number 2 (FEBRUARY)
Start page 260
End page 265
Total pages 6
Publisher Wiley
Place of publication London, Eng.
Publication date 2014
ISSN 1752-4571
Keyword(s) cancer evolution
genomic decay
Tasmanian Devil Facial Tumour Disease
Summary The Tasmanian Devil Facial Tumour Disease (DFTD) provides a unique opportunity to elucidate the long-term effects of natural and anthropogenic selection on cancer evolution. Since first observed in 1996, this transmissible cancer has caused local population declines by >90%. So far, four chromosomal DFTD variants (strains) have been described and karyotypic analyses of 253 tumours showed higher levels of tetraploidy in the oldest strain. We propose that increased ploidy in the oldest strain may have evolved in response to effects of genomic decay observed in asexually reproducing organisms. In this study, we focus on the evolutionary response of DFTD to a disease suppression trial. Tumours collected from devils subjected to the removal programme showed accelerated temporal evolution of tetraploidy compared with tumours from other populations where no increase in tetraploid tumours were observed. As ploidy significantly reduces tumour growth rate, we suggest that the disease suppression trial resulted in selection favouring slower growing tumours mediated by an increased level of tetraploidy. Our study reveals that DFTD has the capacity to rapidly respond to novel selective regimes and that disease eradication may result in novel tumour adaptations, which may further imperil the long-term survival of the world's largest carnivorous marsupial.
Language eng
DOI 10.1111/eva.12117
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2014, Wiley
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Document type: Journal Article
Collection: Centre for Integrative Ecology
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