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Evolution of a contagious cancer: epigenetic variation in devil facial tumour disease

Ujvari, Beata, Pearse, Anne-Maree, Peck, Sarah, Harmsen, Collette, Taylor, Robyn, Pyecroft, Stephen, Madsen, Thomas, Papenfuss, Anthony T. and Belov, Katherine 2012, Evolution of a contagious cancer: epigenetic variation in devil facial tumour disease, Proceedings of the Royal Society B: biological sciences, vol. 280, no. 1750, pp. 2-8, doi: 10.1098/rspb.2012.1720.

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Title Evolution of a contagious cancer: epigenetic variation in devil facial tumour disease
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Pearse, Anne-Maree
Peck, Sarah
Harmsen, Collette
Taylor, Robyn
Pyecroft, Stephen
Madsen, Thomas
Papenfuss, Anthony T.
Belov, Katherine
Journal name Proceedings of the Royal Society B: biological sciences
Volume number 280
Issue number 1750
Start page 2
End page 8
Total pages 7
Publisher Royal Society Publishing
Place of publication London, Eng.
Publication date 2012
ISSN 1471-2954
Keyword(s) cancer
DNA methylation
epigenetic
evolution
tasmanian devil
sarcophilius harrisii
marsupial
Summary The emergence of Devil Facial Tumour Disease (DFTD), a highly contagious cancer, is driving Tasmanian devils (Sarcophilus harrisii) to extinction. The cancer is a genetically and chromosomally stable clonal cell line which is transmitted by biting during social interactions. In the present study, we explore the Devil Facial Tumour (DFT) epigenome and the genes involved in DNA methylation homeostasis. We show that tumour cells have similar levels of methylation to peripheral nerves, the tissue from which DFTD originated. We did not observe any strain or region-specific epimutations. However, we revealed a significant increase in hypomethylation in DFT samples over time (p < 0.0001). We propose that loss of methylation is not because of a maintenance deficiency, as an upregulation of DNA methyltransferase 1 gene was observed in tumours compared with nerves (p < 0.005). Instead, we believe that loss of methylation is owing to active demethylation, supported by the temporal increase in MBD2 and MBD4 (p < 0.001). The implications of these changes on disease phenotypes need to be explored. Our work shows that DFTD should not be treated as a static entity, but rather as an evolving parasite with epigenetic plasticity. Understanding the role of epimutations in the evolution of this parasitic cancer will provide unique insights into the role of epigenetic plasticity in cancer evolution and progression in traditional cancers that arise and die with their hosts.
Language eng
DOI 10.1098/rspb.2012.1720
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Royal Society Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063799

Document type: Journal Article
Collection: Centre for Integrative Ecology
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