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New insights into the role of MHC diversity in devil facial tumour disease

Lane, Amanda, Cheng, Yuanyuan, Wright, Belinda, Hamede, Rodrigo, Levan, Laura, Jones, Menna, Ujvari, Beata and Belov, Katherine 2012, New insights into the role of MHC diversity in devil facial tumour disease, PLoS one, vol. 7, no. 6, pp. 1-9, doi: 10.1371/journal.pone.0036955.

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Title New insights into the role of MHC diversity in devil facial tumour disease
Author(s) Lane, Amanda
Cheng, Yuanyuan
Wright, Belinda
Hamede, Rodrigo
Levan, Laura
Jones, Menna
Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Belov, Katherine
Journal name PLoS one
Volume number 7
Issue number 6
Start page 1
End page 9
Total pages 9
Publisher Public Library of Science
Place of publication San Fransico, Calif.
Publication date 2012
ISSN 1932-6203
Keyword(s) tasmanian devil
tumour
DFTD
evolution
cancer
marsupial
Summary Devil facial tumour disease (DFTD) is a fatal contagious cancer that has decimated Tasmanian devil populations. The tumour has spread without invoking immune responses, possibly due to low levels of Major Histocompatibility Complex (MHC) diversity in Tasmanian devils. Animals from a region in north-western Tasmania have lower infection rates than those in the east of the state. This area is a genetic transition zone between sub-populations, with individuals from north-western Tasmania displaying greater diversity than eastern devils at MHC genes, primarily through MHC class I gene copy number variation. Here we test the hypothesis that animals that remain healthy and tumour free show predictable differences at MHC loci compared to animals that develop the disease.
Language eng
DOI 10.1371/journal.pone.0036955
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Public Library of Science
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063804

Document type: Journal Article
Collections: Open Access Collection
Centre for Integrative Ecology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.