Do natural antibodies compensate for humoral immunosenescence in tropical pythons?

Ujvari, Beata and Madsen, Thomas 2011, Do natural antibodies compensate for humoral immunosenescence in tropical pythons?, Functional ecology, vol. 25, no. 4, pp. 813-817, doi: 10.1111/j.1365-2435.2011.01860.x.

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Title Do natural antibodies compensate for humoral immunosenescence in tropical pythons?
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata
Madsen, Thomas
Journal name Functional ecology
Volume number 25
Issue number 4
Start page 813
End page 817
Total pages 5
Publisher Wiley
Place of publication London, Eng.
Publication date 2011
ISSN 1365-2435
Keyword(s) ageing
humoral immune response
natural antibodies
Summary Ageing is frequently claimed to result in an age-dependent deterioration in immune function. Our results, however, based on 30 known-aged water pythons (Liasis fuscus; age ranging from <1 to 18 years) immunized with keyhole limpet haemocyanin (KLH), demonstrate that age-related changes in immune function may follow different and opposing pathways. Python-specific humoral antibodies (SpAb) showed an age-dependent decrease in cross-reactivity to KLH, whereas natural antibodies (NAbs) ability to bind to this antigen increased with age. Notably, when humoral SpAb and NAb titres were combined, no effect of age was detected in antibody cross-reactivity, strongly suggesting that NAbs may play a crucial role in maintaining immunocompetence during the ageing process.
Language eng
DOI 10.1111/j.1365-2435.2011.01860.x
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
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