Do natural antibodies compensate for humoral immunosenescence in tropical pythons? Ujvari, Beata and Madsen, Thomas 2011, Do natural antibodies compensate for humoral immunosenescence in tropical pythons?, Functional ecology, vol. 25, no. 4, pp. 813-817, doi: 10.1111/j.1365-2435.2011.01860.x. Attached Files Name Description MIMEType Size Downloads Title Do natural antibodies compensate for humoral immunosenescence in tropical pythons? Author(s) Ujvari, Beata orcid.org/0000-0003-2391-2988 Madsen, Thomas Journal name Functional ecology Volume number 25 Issue number 4 Start page 813 End page 817 Total pages 5 Publisher Wiley Place of publication London, Eng. Publication date 2011 ISSN 1365-2435 Keyword(s) ageing humoral immune response immunosenescence KLH natural antibodies snake Summary Ageing is frequently claimed to result in an age-dependent deterioration in immune function. Our results, however, based on 30 known-aged water pythons (Liasis fuscus; age ranging from <1 to 18 years) immunized with keyhole limpet haemocyanin (KLH), demonstrate that age-related changes in immune function may follow different and opposing pathways. Python-specific humoral antibodies (SpAb) showed an age-dependent decrease in cross-reactivity to KLH, whereas natural antibodies (NAbs) ability to bind to this antigen increased with age. Notably, when humoral SpAb and NAb titres were combined, no effect of age was detected in antibody cross-reactivity, strongly suggesting that NAbs may play a crucial role in maintaining immunocompetence during the ageing process. Language eng DOI 10.1111/j.1365-2435.2011.01860.x Field of Research 069999 Biological Sciences not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30063809 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment Centre for Integrative Ecology Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 02 Jun 2014, 10:08:59 EST Mon, 02 Jun 2014, 13:17:04 EST Thu, 12 Jun 2014, 12:03:11 EST Mon, 16 Jun 2014, 11:56:44 EST Thu, 11 Dec 2014, 20:25:42 EST Wed, 18 Nov 2015, 06:33:22 EST Filtered Full Citation counts:   Cited 23 times in TR Web of Science Cited 26 times in Scopus Search Google Scholar Access Statistics: 334 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Mon, 02 Jun 2014, 10:08:59 EST

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