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Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

Gao, Dingcheng, Nolan, Daniel J., Mellick, Albert S., Bambino, Kathryn, McDonnell, Kevin and Mittal, Vivek 2008, Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis, Science, vol. 319, no. 5860, pp. 195-198, doi: 10.1126/science.1150224.

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Title Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
Author(s) Gao, Dingcheng
Nolan, Daniel J.
Mellick, Albert S.
Bambino, Kathryn
McDonnell, Kevin
Mittal, Vivek
Journal name Science
Volume number 319
Issue number 5860
Start page 195
End page 198
Total pages 4
Publisher American Association for the Advancement of Science
Place of publication Washington, D. C.
Publication date 2008
ISSN 1095-9203
0036-8075
Keyword(s) progenitor cells
mouse lung
metastasis
angiogenic switch
Summary Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)–derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.
Language eng
DOI 10.1126/science.1150224
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, American Association for the Advancement of Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063826

Document type: Journal Article
Collection: School of Medicine
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