Effect of sodium bicarbonate on [HCO3 -], pH, and gastrointestinal symptoms

Carr, Amelia J., Slater, Gary J., Gore, Christopher J., Dawson, Brian and Burke, Louise M. 2011, Effect of sodium bicarbonate on [HCO3 -], pH, and gastrointestinal symptoms, International journal of sport nutrition & exercise metabolism, vol. 21, no. 3, pp. 189-194.

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Title Effect of sodium bicarbonate on [HCO3 -], pH, and gastrointestinal symptoms
Author(s) Carr, Amelia J.ORCID iD for Carr, Amelia J. orcid.org/0000-0003-3855-2540
Slater, Gary J.
Gore, Christopher J.
Dawson, Brian
Burke, Louise M.
Journal name International journal of sport nutrition & exercise metabolism
Volume number 21
Issue number 3
Start page 189
End page 194
Total pages 7
Publisher Human Kinetics Journals
Place of publication Champaign, Il.
Publication date 2011
ISSN 1526-484X
Keyword(s) buffering
ergogenic aid
induced alkalosis
Summary Context: Sodium bicarbonate (NaHCO3) is often ingested at a dose of 0.3 g/kg body mass (BM), but ingestion protocols are inconsistent in terms of using solution or capsules, ingestion period, combining NaHCO3 with sodium citrate (Na3C6H5O7), and coingested food and fluid. Purpose: To quantify the effect of ingesting 0.3 g/ kg NaHCO3 on blood pH, [HCO3 -], and gastrointestinal (GI) symptoms over the subsequent 3 hr using a range of ingestion protocols and, thus, to determine an optimal protocol. Methods: In a crossover design, 13 physically active subjects undertook 8 NaHCO3 experimental ingestion protocols and 1 placebo protocol. Capillary blood was taken every 30 min and analyzed for pH and [HCO3 -]. GI symptoms were quantified every 30 min via questionnaire. Statistics used were pairwise comparisons between protocols; differences were interpreted in relation to smallest worthwhile changes for each variable. A likelihood of >75% was a substantial change. Results: [HCO3 -] and pH were substantially greater than in placebo for all other ingestion protocols at almost all time points. When NaHCO3 was coingested with food, the greatest [HCO3 -] (30.9 mmol/kg) and pH (7.49) and lowest incidence of GI symptoms were observed. The greatest incidence of GI side effects was observed 90 min after ingestion of 0.3 g/kg NaHCO3 solution. Conclusions: The changes in pH and [HCO3 -] for the 8 NaHCO3-ingestion protocols were similar, so an optimal protocol cannot be recommended. However, the results suggest that NaHCO3 coingested with a high-carbohydrate meal should be taken 120-150 min before exercise to induce substantial blood alkalosis and reduce GI symptoms. ABSTRACT FROM AUTHOR
Language eng
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063876

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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