Effect of sodium bicarbonate on [HCO3 -], pH, and gastrointestinal symptoms Carr, Amelia J., Slater, Gary J., Gore, Christopher J., Dawson, Brian and Burke, Louise M. 2011, Effect of sodium bicarbonate on [HCO3 -], pH, and gastrointestinal symptoms, International journal of sport nutrition & exercise metabolism, vol. 21, no. 3, pp. 189-194. Attached Files Name Description MIMEType Size Downloads Title Effect of sodium bicarbonate on [HCO3 -], pH, and gastrointestinal symptoms Author(s) Carr, Amelia J. orcid.org/0000-0003-3855-2540 Slater, Gary J. Gore, Christopher J. Dawson, Brian Burke, Louise M. Journal name International journal of sport nutrition & exercise metabolism Volume number 21 Issue number 3 Start page 189 End page 194 Total pages 7 Publisher Human Kinetics Journals Place of publication Champaign, Il. Publication date 2011 ISSN 1526-484X Keyword(s) buffering ergogenic aid induced alkalosis Summary Context: Sodium bicarbonate (NaHCO3) is often ingested at a dose of 0.3 g/kg body mass (BM), but ingestion protocols are inconsistent in terms of using solution or capsules, ingestion period, combining NaHCO3 with sodium citrate (Na3C6H5O7), and coingested food and fluid. Purpose: To quantify the effect of ingesting 0.3 g/ kg NaHCO3 on blood pH, [HCO3 -], and gastrointestinal (GI) symptoms over the subsequent 3 hr using a range of ingestion protocols and, thus, to determine an optimal protocol. Methods: In a crossover design, 13 physically active subjects undertook 8 NaHCO3 experimental ingestion protocols and 1 placebo protocol. Capillary blood was taken every 30 min and analyzed for pH and [HCO3 -]. GI symptoms were quantified every 30 min via questionnaire. Statistics used were pairwise comparisons between protocols; differences were interpreted in relation to smallest worthwhile changes for each variable. A likelihood of >75% was a substantial change. Results: [HCO3 -] and pH were substantially greater than in placebo for all other ingestion protocols at almost all time points. When NaHCO3 was coingested with food, the greatest [HCO3 -] (30.9 mmol/kg) and pH (7.49) and lowest incidence of GI symptoms were observed. The greatest incidence of GI side effects was observed 90 min after ingestion of 0.3 g/kg NaHCO3 solution. Conclusions: The changes in pH and [HCO3 -] for the 8 NaHCO3-ingestion protocols were similar, so an optimal protocol cannot be recommended. However, the results suggest that NaHCO3 coingested with a high-carbohydrate meal should be taken 120-150 min before exercise to induce substantial blood alkalosis and reduce GI symptoms. ABSTRACT FROM AUTHOR Language eng Field of Research 069999 Biological Sciences not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30063876 Document type: Journal Article Collections: Faculty of Health School of Psychology Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 02 Jun 2014, 10:20:29 EST Mon, 02 Jun 2014, 15:25:07 EST Thu, 28 Aug 2014, 07:43:31 EST Thu, 11 Dec 2014, 20:27:55 EST Tue, 06 Feb 2018, 11:40:08 EST Filtered Full Citation counts:   Cited 74 times in TR Web of Science Cited 80 times in Scopus Search Google Scholar Access Statistics: 426 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Mon, 02 Jun 2014, 10:20:29 EST

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