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Telomere dynamics and homeostasis in a transmissible cancer

Ujvari, Beata, Pearse, Anne-Maree, Taylor, Robyn, Pyecroft, Stephen, Flanagan, Cassandra, Gombert, Sara, Papenfuss, Anthony T., Madsen, Thomas and Belov, Katherine 2012, Telomere dynamics and homeostasis in a transmissible cancer, PLoS one, vol. 7, no. 8, pp. 1-8, doi: 10.1371/journal.pone.0044085.

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Title Telomere dynamics and homeostasis in a transmissible cancer
Author(s) Ujvari, BeataORCID iD for Ujvari, Beata orcid.org/0000-0003-2391-2988
Pearse, Anne-Maree
Taylor, Robyn
Pyecroft, Stephen
Flanagan, Cassandra
Gombert, Sara
Papenfuss, Anthony T.
Madsen, Thomas
Belov, Katherine
Journal name PLoS one
Volume number 7
Issue number 8
Start page 1
End page 8
Total pages 8
Publisher Public Library of Science
Place of publication San Fransico, Calif.
Publication date 2012
ISSN 1932-6203
Keyword(s) tasmanian devil
tumour
DFTD
evolution
cancer
marsupial
Summary Devil Facial Tumour Disease (DFTD) is a unique clonal cancer that threatens the world's largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii) with extinction. This transmissible cancer is passed between individual devils by cell implantation during social interactions. The tumour arose in a Schwann cell of a single devil over 15 years ago and since then has expanded clonally, without showing signs of replicative senescence; in stark contrast to a somatic cell that displays a finite capacity for replication, known as the “Hayflick limit”.
Language eng
DOI 10.1371/journal.pone.0044085
Field of Research 069999 Biological Sciences not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Public Library of Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30063890

Document type: Journal Article
Collections: Open Access Collection
Centre for Integrative Ecology
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.