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Adefovir dipivoxil and pegylated interferon alpha for the treatment of chronic hepatitis B: an updated systematic review and economic evaluation

Jones, J., Sheperd, J., Baxter, L., Gospodarevskaya, E., Hartwell, D., Harris, P. and Price, E. 2009, Adefovir dipivoxil and pegylated interferon alpha for the treatment of chronic hepatitis B: an updated systematic review and economic evaluation, Health technology assessment, vol. 13, no. 35, pp. 1-196.

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Title Adefovir dipivoxil and pegylated interferon alpha for the treatment of chronic hepatitis B: an updated systematic review and economic evaluation
Author(s) Jones, J.
Sheperd, J.
Baxter, L.
Gospodarevskaya, E.
Hartwell, D.
Harris, P.
Price, E.
Journal name Health technology assessment
Volume number 13
Issue number 35
Start page 1
End page 196
Total pages 196
Publisher NIHR Journals Library
Place of publication Southampton, Eng.
Publication date 2009-07
ISSN 1366-5278
2046-4924
Summary To update and extend a 2006 report on the clinical effectiveness and cost-effectiveness of adefovir dipivoxil (ADV) and pegylated interferon alpha (PEG-alpha) for the treatment of chronic hepatitis B (CHB). Thirteen bibliographic databases were searched including MEDLINE, EMBASE and the Cochrane Library. Searches were run from the beginning of 2005 to September 2007. For the clinical effectiveness review, randomised controlled trials (RCTs) comparing ADV, PEG-alpha-2a and PEG-alpha-2b with currently licensed treatments for CHB, including non-pegylated interferon alpha (IFN-alpha) and lamivudine (LAM), were included. Outcomes included biochemical, histological and virological response to treatment, drug resistance and adverse effects. A systematic review of economic evaluations of antiviral treatments for CHB was conducted. The economic Markov model used in the 2006 report was updated in terms of utility values, discount rates and costs. `
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Queen’s Printer and Controller of HMSO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30064295

Document type: Journal Article
Collections: Population Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.