You are not logged in.

Frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude

Lechner-Scott, J., Spencer, B., de Malmanche, T., Attia, J., Fitzgerald, M., Trojano, M., Grand'Maison, F., Gomez, J. Antonio C., Izquierdo, G., Duquette, P., Girard, M., Grammond, P., Oreja-Guevara, C., Hupperts, R., Bergamaschi, P., Boz, C., Giuliani, G., van Pesch, V., Iuliano, G., Fiol, M., Cristiano, E., Verheul, F., Laura Saladino, M., Slee, M., Barnett, M., Deri, N., Flechter, S., Vella, N., Shaw, C., Herbert, J., Moore, F., Petkovska-Boskova, T., Jokubaitis, V. and Butzkueven, H. 2011, Frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude, Multiple sclerosis, vol. 18, no. 7, pp. 974-982, doi: 10.1177/1352458511431729.

Attached Files
Name Description MIMEType Size Downloads

Title Frequency of CSF oligoclonal banding in multiple sclerosis increases with latitude
Author(s) Lechner-Scott, J.
Spencer, B.
de Malmanche, T.
Attia, J.
Fitzgerald, M.
Trojano, M.
Grand'Maison, F.
Gomez, J. Antonio C.
Izquierdo, G.
Duquette, P.
Girard, M.
Grammond, P.
Oreja-Guevara, C.
Hupperts, R.
Bergamaschi, P.
Boz, C.
Giuliani, G.
van Pesch, V.
Iuliano, G.
Fiol, M.
Cristiano, E.
Verheul, F.
Laura Saladino, M.
Slee, M.
Barnett, M.
Deri, N.
Flechter, S.
Vella, N.
Shaw, C.
Herbert, J.
Moore, F.
Petkovska-Boskova, T.
Jokubaitis, V.
Butzkueven, H.
Journal name Multiple sclerosis
Volume number 18
Issue number 7
Start page 974
End page 982
Total pages 9
Publisher Sage
Place of publication London, Eng.
Publication date 2011-07
ISSN 1477-0970
Keyword(s) multiple sclerosis
cerebrospinal fluid
oligoclonal bands
adult
cross-sectional studies
incidence
male
registries
Summary With the advent of MRI scanning, the value of lumbar puncture to assess oligoclonal band (OCB) status-for the diagnosis of multiple sclerosis (MS) is increasingly uncertain. One major issue is that the reported frequency of cerebrospinal fluid (CSF)-restricted oligoclonal banding for the diagnosis of MS varies considerably in different studies. In addition, the relationship between OCB positivity and disease outcome remains uncertain, as reported studies are generally too small to assess comparative disability outcomes with sufficient power. In order to further investigate variation of OCB positivity in patients with MS, we utilized MSBase, a longitudinal, Web-based collaborative MS outcomes registry following clinical cohorts in several continents and latitudes. We also assessed whether OCB positivity affects long-term disability outcome. A total of 13,242 patient records were obtained from 37 MS specialist centres in 19 different countries. OCB status was documented in 4481 (34%) patients and 80% of these were OCB positive. The presence of OCB was associated with degree of latitude (p = 0.02). Furthermore, the outcome of patients negative for CSF-specific OCB was significantly better in comparison to the OCB positive patients, as assessed by Expanded Disability Status Scale change (p < 0.001). The results of this study indicate that latitude could explain some of the inconsistencies in OCB status reported in different populations. The study confirms that OCB positivity in MS is associated with a worse long-term prognosis.
Language eng
DOI 10.1177/1352458511431729
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Sage Publications
Persistent URL http://hdl.handle.net/10536/DRO/DU:30064342

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in TR Web of Science
Scopus Citation Count Cited 27 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 62 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Fri, 13 Jun 2014, 12:03:11 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.