The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action
McBrien, Neville A., Arumugam, Baskar, Gentle, Alex, Chow, Anna and Sahebjada, Srujana 2011, The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action, Ophthalmic & physiological optics, vol. 31, no. 5, pp. 529-539, doi: 10.1111/j.1475-1313.2011.00841.x.
Attached Files
Name
Description
MIMEType
Size
Downloads
Title
The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action
It is well established that the broad-band muscarinic antagonist, atropine is effective at inhibiting the progression of myopia and does so by preventing the elongation of the vitreous chamber of the eye. However, uncertainty remains as to whether this effect occurs through a receptoral mechanism and, if so, which muscarinic receptor subtype mediates this effect. Previous work, in avian and mammalian models of myopia, implicates the M1 and M4 receptors as potential targets. The current study used physiologically relevant concentrations of highly selective muscarinic antagonists (MT-3 and MT-7) to further characterise the role of the M4 receptor in the control of myopia in the chick model of refractive development.
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO.
If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.