The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action McBrien, Neville A., Arumugam, Baskar, Gentle, Alex, Chow, Anna and Sahebjada, Srujana 2011, The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action, Ophthalmic & physiological optics, vol. 31, no. 5, pp. 529-539, doi: 10.1111/j.1475-1313.2011.00841.x. Attached Files Name Description MIMEType Size Downloads Title The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action Author(s) McBrien, Neville A. Arumugam, Baskar Gentle, Alex orcid.org/0000-0003-0661-4196 Chow, Anna Sahebjada, Srujana Journal name Ophthalmic & physiological optics Volume number 31 Issue number 5 Start page 529 End page 539 Total pages 11 Publisher Blackwell Publishers Place of publication Oxford, Eng. Publication date 2011-09 ISSN 1475-1313 Keyword(s) muscarinic antagonists pharmacology myopia pathology receptor animals newborn biometry chickens intravitreal injections myopia/drug therapy Summary It is well established that the broad-band muscarinic antagonist, atropine is effective at inhibiting the progression of myopia and does so by preventing the elongation of the vitreous chamber of the eye. However, uncertainty remains as to whether this effect occurs through a receptoral mechanism and, if so, which muscarinic receptor subtype mediates this effect. Previous work, in avian and mammalian models of myopia, implicates the M1 and M4 receptors as potential targets. The current study used physiologically relevant concentrations of highly selective muscarinic antagonists (MT-3 and MT-7) to further characterise the role of the M4 receptor in the control of myopia in the chick model of refractive development. Language eng DOI 10.1111/j.1475-1313.2011.00841.x Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2011, Blackwell Publishers Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30064349 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Link to full-text (open access)   Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Fri, 13 Jun 2014, 12:03:52 EST Mon, 16 Jun 2014, 13:24:32 EST Fri, 20 Jun 2014, 13:23:18 EST Fri, 10 Oct 2014, 09:20:39 EST Thu, 11 Dec 2014, 20:35:22 EST Wed, 23 Dec 2020, 04:36:58 EST Filtered Full Citation counts:   Cited 29 times in TR Web of Science Cited 36 times in Scopus Search Google Scholar Access Statistics: 451 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Fri, 13 Jun 2014, 12:03:52 EST

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