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The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action

McBrien, Neville A., Arumugam, Baskar, Gentle, Alex, Chow, Anna and Sahebjada, Srujana 2011, The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action, Ophthalmic & physiological optics, vol. 31, no. 5, pp. 529-539, doi: 10.1111/j.1475-1313.2011.00841.x.

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Title The M4 muscarinic antagonist MT-3 inhibits myopia in chick: evidence for site of action
Author(s) McBrien, Neville A.
Arumugam, Baskar
Gentle, AlexORCID iD for Gentle, Alex orcid.org/0000-0003-0661-4196
Chow, Anna
Sahebjada, Srujana
Journal name Ophthalmic & physiological optics
Volume number 31
Issue number 5
Start page 529
End page 539
Total pages 11
Publisher Blackwell Publishers
Place of publication Oxford, Eng.
Publication date 2011-09
ISSN 1475-1313
Keyword(s) muscarinic antagonists
pharmacology
myopia
pathology
receptor
animals
newborn
biometry
chickens
intravitreal injections
myopia/drug therapy
Summary It is well established that the broad-band muscarinic antagonist, atropine is effective at inhibiting the progression of myopia and does so by preventing the elongation of the vitreous chamber of the eye. However, uncertainty remains as to whether this effect occurs through a receptoral mechanism and, if so, which muscarinic receptor subtype mediates this effect. Previous work, in avian and mammalian models of myopia, implicates the M1 and M4 receptors as potential targets. The current study used physiologically relevant concentrations of highly selective muscarinic antagonists (MT-3 and MT-7) to further characterise the role of the M4 receptor in the control of myopia in the chick model of refractive development.
Language eng
DOI 10.1111/j.1475-1313.2011.00841.x
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Blackwell Publishers
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30064349

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.