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The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep

Pelosi, Assunta, Piedrafita, David, De, Guzman Giorgio, Shepherd, Robert, Hamill, John D., Meeusen, Els and Walmsley, Amanda M. 2012, The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep, PLoS one, vol. 7, no. 12, pp. 1-9, doi: 10.1371/journal.pone.0052907.

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Title The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep
Author(s) Pelosi, Assunta
Piedrafita, David
De, Guzman Giorgio
Shepherd, Robert
Hamill, John D.
Meeusen, Els
Walmsley, Amanda M.
Journal name PLoS one
Volume number 7
Issue number 12
Article ID e52907
Start page 1
End page 9
Total pages 9
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2012
ISSN 1932-6203
Keyword(s) immunology
vaccine
vet immunology
Summary Antigen-specific antibody responses against a model antigen (the B subunit of the heat labile toxin of enterotoxigenic Escherichia coli, LTB) were studied in sheep following oral immunisation with plant-made and delivered vaccines. Delivery from a root-based vehicle resulted in antigen-specific immune responses in mucosal secretions of the abomasum and small intestine and mesenteric lymph nodes. Immune responses from the corresponding leaf-based vaccine were more robust and included stimulation of antigen-specific antibodies in mucosal secretions of the abomasum. These findings suggest that oral delivery of a plant bioencapsulated antigen can survive passage through the rumen to elicit mucosal and systemic immune responses in sheep. Moreover, the plant tissue used as the vaccine delivery vehicle affects the magnitude of these responses.
Language eng
DOI 10.1371/journal.pone.0052907
Field of Research 079999 Agricultural and Veterinary Sciences not elsewhere classified
Socio Economic Objective 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Grant ID ARC LP088231
Copyright notice ©2012, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30064363

Document type: Journal Article
Collections: Office of the Deputy Vice-Chancellor Research
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.