Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdala

Yamasue, H., Kakiuchi, C., Tochigi, M., Inoue, H., Suga, M., Abe, O., Yamada, H., Sasaki, T., Rogers, M.A., Aoki, S., Kato, T. and Kasai, K. 2008, Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdala, Genes, brain and behavior, vol. 7, no. 6, pp. 698-704, doi: 10.1111/j.1601-183X.2008.00408.x.

Attached Files
Name Description MIMEType Size Downloads

Title Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdala
Author(s) Yamasue, H.
Kakiuchi, C.
Tochigi, M.
Inoue, H.
Suga, M.
Abe, O.
Yamada, H.
Sasaki, T.
Rogers, M.A.ORCID iD for Rogers, M.A.
Aoki, S.
Kato, T.
Kasai, K.
Journal name Genes, brain and behavior
Volume number 7
Issue number 6
Start page 698
End page 704
Total pages 7
Publisher Wiley
Place of publication London, Eng.
Publication date 2008-08
ISSN 1601-183X
Keyword(s) amygdala
bipolar disorder
voxel-based morphometry
Summary Mitochondrial calcium regulation plays a number of important roles in neurons. Mitochondrial DNA (mtDNA) is highly polymorphic, and its interindividual variation is associated with various neuropsychiatric diseases and mental functions. An mtDNA polymorphism, 10398A>G, was reported to affect mitochondrial calcium regulation. Volume of hippocampus and amygdala is reportedly associated with various mental disorders and mental functions and is regarded as an endophenotype of mental disorders. The present study investigated the relationship between the mtDNA 10398A>G polymorphism and the volume of hippocampus and amygdala in 118 right-handed healthy subjects. The brain morphometry using magnetic resonance images employed both manual tracing volumetry in the native space and voxel-based morphometry (VBM) in the spatially normalized space. Amygdala volume was found to be significantly larger in healthy subjects with 10398A than in those with 10398G by manual tracing, which was confirmed by the VBM. Brain volumes in the other gray matter regions and all white matter regions showed no significant differences associated with the polymorphism. These provocative findings might provide a clue to the complex relationship between mtDNA, brain structure and mental disorders.
Language eng
DOI 10.1111/j.1601-183X.2008.00408.x
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Wiley
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in TR Web of Science
Scopus Citation Count Cited 9 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 304 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Fri, 13 Jun 2014, 12:14:47 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact