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Comfort response of three silicone hydrogel daily disposable contact lenses

Varikooty, Jalaiah, Keir, Nancy, Richter, Doris, Jones, Lyndon W., Woods, Craig and Fonn, Desmond 2013, Comfort response of three silicone hydrogel daily disposable contact lenses, Optometry & vision science, vol. 90, no. 9, pp. 945-953, doi: 10.1097/OPX.0b013e31829d8dbf.

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Title Comfort response of three silicone hydrogel daily disposable contact lenses
Author(s) Varikooty, Jalaiah
Keir, Nancy
Richter, Doris
Jones, Lyndon W.
Woods, Craig
Fonn, Desmond
Journal name Optometry & vision science
Volume number 90
Issue number 9
Start page 945
End page 953
Total pages 9
Publisher American Academy of Optometry
Place of publication Orlando, Flo.
Publication date 2013
ISSN 1538-9235
Keyword(s) contact lens
silicone hydrogels
daily disposable
comfort
Summary To evaluate subjective ocular comfort across the day with three silicone hydrogel daily disposables (SHDDs) in a group of adapted lens wearers. Masked subjects (asymptomatic or symptomatic of end-of-day (EOD) dryness with habitual lenses) wore three SHDDs: DAILIES TOTAL1 (DT1), Clariti 1day (C1D), or 1-DAY ACUVUE TRUEYE (AVTE), each for 3 days. On day 2, wearing time (WT) and comfort ratings after insertion, at 4, 8, and 12 hours, and at EOD were recorded. Because not all subjects wore lenses for 12 hours, comfort was analyzed across the day (up to 8 hours, 8 to 12 hours), and a new variable (“cumulative comfort” [CC]) was calculated for EOD. One hundred four subjects completed the study (51 asymptomatic, 53 symptomatic). The two groups had different WTs (mean WT, 14.0 and 12.7 hours, respectively; p < 0.001). Ocular comfort was rated higher in the asymptomatic group throughout the day (p < 0.001). One hundred four subjects wore all three SHDDs for at least 8 hours, whereas 74 (45 asymptomatic, 29 symptomatic) subjects wore them for 12 hours or longer. Comfort ratings were higher with DT1 (least square means [LSM] = 91.0) than with C1D (LSM = 86.5; p < 0.001) and AVTE (LSM = 87.7; p = 0.011) for the first 8 hours and lower with C1D compared with DT1 (p = 0.012) from 8 to 12 hours. Mean EOD (± SD) comfort with the C1D lens was 72 ± 21, lower than both DT1 (mean, 79 ± 17; p = 0.001) and AVTE (mean, 78 ± 21; p = 0.010). Mean CC was higher in the asymptomatic group (mean, 1261 ± 59) compared with that in the symptomatic group (mean, 1009 ± 58; p < 0.001) and higher for DT1 (mean, 1184 ± 258) than C1D (mean, 1094 ± 318; p = 0.002) and AVTE (mean, 1122 ± 297; p = 0.046). All three SHDDs had average WTs of 12 hours or longer for 1 day. Comfort during the first 12 hours was highest with DT1 (similar to AVTE between 8 and 12 hours) and lowest with C1D. End-of-day comfort was lowest with C1D, and CC was highest for DT1. Cumulative comfort may be a valuable new metric to assess ocular comfort during the day.
Language eng
DOI 10.1097/OPX.0b013e31829d8dbf
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, American Academy of Optometry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30064709

Document type: Journal Article
Collection: School of Medicine
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