Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits

Michaels, Sylvia, Eppel, Gabriela A., Burke, Sandra L., Head, Geoffrey A., Armitage, James, Carrol, Joan F., Malpas, Simon C. and Evans, Roger E. 2009, Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits, Renal physiology, vol. 296, pp. 1889-1896, doi: 10.1152/ajpregu.90931.2008.

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Title Altered responsiveness of the kidney to activation of the renal nerves in fat-fed rabbits
Author(s) Michaels, Sylvia
Eppel, Gabriela A.
Burke, Sandra L.
Head, Geoffrey A.
Armitage, JamesORCID iD for Armitage, James
Carrol, Joan F.
Malpas, Simon C.
Evans, Roger E.
Journal name Renal physiology
Volume number 296
Start page 1889
End page 1896
Total pages 8
Publisher Biomedical Information Project, University of Sheffield
Place of publication Sheffield, Eng.
Publication date 2009
ISSN 0300-3434
Summary We tested whether mild adiposity alters responsiveness of the kidney to activation of the renal sympathetic nerves. After rabbits were fed a high-fat or control diet for 9 wk, responses to reflex activation of renal sympathetic nerve activity (RSNA) with hypoxia and electrical stimulation of the renal nerves (RNS) were examined under pentobarbital anesthesia. Fat pad mass and body weight were, respectively, 74% and 6% greater in fat-fed rabbits than controls. RNS produced frequency-dependent reductions in renal blood flow, cortical and medullary perfusion, glomerular filtration rate, urine flow, and sodium excretion and increased renal plasma renin activity (PRA) overflow. Responses of sodium excretion and medullary perfusion were significantly enhanced by fat feeding. For example, 1 Hz RNS reduced sodium excretion by 79 ± 4% in fat-fed rabbits and 46 ± 13% in controls. RNS (2 Hz) reduced medullary perfusion by 38 ± 11% in fat-fed rabbits and 9 ± 4% in controls. Hypoxia doubled RSNA, increased renal PRA overflow and medullary perfusion, and reduced urine flow and sodium excretion, without significantly altering mean arterial pressure (MAP) or cortical perfusion. These effects were indistinguishable in fat-fed and control rabbits. Neither MAP nor PRA were significantly greater in conscious fat-fed than control rabbits. These observations suggest that mild excess adiposity can augment the antinatriuretic response to renal nerve activation by RNS, possibly through altered neural control of medullary perfusion. Thus, sodium retention in obesity might be driven not only by increased RSNA, but also by increased responsiveness of the kidney to RSNA.
Language eng
DOI 10.1152/ajpregu.90931.2008
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Biomedical Information Project, University of Sheffield
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School of Medicine
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