Developmental origins of obesity and the metabolic syndrome : the role of maternal obesity

Armitage, James Andrew, Poston, Lucilla and Taylor, Paul David 2008, Developmental origins of obesity and the metabolic syndrome : the role of maternal obesity, Obesity and metabolism, vol. 36, pp. 73-84, doi: 10.1159/000115355.

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Title Developmental origins of obesity and the metabolic syndrome : the role of maternal obesity
Author(s) Armitage, James AndrewORCID iD for Armitage, James Andrew orcid.org/0000-0002-3762-0911
Poston, Lucilla
Taylor, Paul David
Journal name Obesity and metabolism
Volume number 36
Start page 73
End page 84
Total pages 12
Publisher Karger
Place of publication Zurich, Switzerland
Publication date 2008
ISSN 0301-3073
1662-3762
Summary Obesity and its sequelae may prove to be the greatest threat to human lifestyle and health in the developed world this century. The so called obesity epidemic has seen the incidence of obesity and overweight almost double in Western societies and the trend is mirrored in nations that are transitioning to first world economies. There is no doubt that much of the rise in obesity can be attributed to lifestyle factors such as the excess consumption of energy-dense foods and the decline in physical activity. However, the ‘fetal origins’hypothesis, first proposed by Barker and colleagues and elaborated by several groups over the past 15 years to be termed the ‘Developmental Origins of Adult Health and Disease’ (DOHaD), provides an alternative explanation for the rising rates of obesity. The DOHaD hypothesis states that exposure to an unfavourable environment during development (either in utero or in the early postnatal period) programmes changes in fetal or neonatal development such that the individual is then at greater risk of developing adulthood disease. This chapter discusses the effects of maternal obesity on fetal development and birth outcomes as well as the manner in which DOHaD may contribute to the obesity epidemic.
Language eng
DOI 10.1159/000115355
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, Karger
Persistent URL http://hdl.handle.net/10536/DRO/DU:30064855

Document type: Journal Article
Collection: School of Medicine
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