Neurobiology of schizophrenia spectrum disorders: The role of oxidative stress

Wood, S. J., Yucel, M., Pantelis, C. and Berk, M. 2009, Neurobiology of schizophrenia spectrum disorders: The role of oxidative stress, Annals of the Academy of Medicine Singapore, vol. 38, no. 5, pp. 396-401.

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Title Neurobiology of schizophrenia spectrum disorders: The role of oxidative stress
Author(s) Wood, S. J.
Yucel, M.
Pantelis, C.
Berk, M.ORCID iD for Berk, M.
Journal name Annals of the Academy of Medicine Singapore
Volume number 38
Issue number 5
Start page 396
End page 401
Total pages 6
Publisher Academy of Medicine Singapore
Place of publication Singapore
Publication date 2009-05
ISSN 0304-4602
Keyword(s) Glutathione
Magnetic resonance spectroscopy
N-acetyl cysteine
Summary Mitochondrial dysfunction and oxidative stress are increasingly implicated in the pathophysiology of schizophrenia. The brain is the body's highest energy consumer, and the glutathione system is the brain's dominant free radical scavenger. In the current paper, we review the evidence of central and peripheral nervous system anomalies in the oxidative defences of individuals with schizophrenia, principally involving the glutathione system. This is reflected by evidence of the manifold consequences of oxidative stress that include lipid peroxidation, protein carboxylation, DNA damage and apoptosis - all potentially part of the process of neuroprogression in the disorder. Importantly, oxidative stress is amenable to intervention. We consider the clinical potential of some possible interventions that help reduce oxidative stress, via augmentation of the glutathione system, particularly N-acetyl cysteine. We argue that a better understanding of the mechanisms and pathways underlying oxidative stress will assist in developing the therapeutic potential of this area.
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C4.1 Letter or note
Copyright notice ©2009, Academy of Medicine Singapore
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Document type: Journal Article
Collection: School of Medicine
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