A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania Kulkarni, Jayashri, Berk, Michael, Wang, Wei, Mu, Ling, Scarr, Elizabeth, Van Rheenen, Tamsyn E., Worsely, Roisin, Gurvich, Caroline, Gavrilidis, Emorfia, de Castella, Anthony, Fitzgerald, Paul and David, Susan R. 2014, A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania, Psychoneuroendocrinology, vol. 43, pp. 52-61, doi: 10.1016/j.psyneuen.2014.02.004. Attached Files Name Description MIMEType Size Downloads Title A four week randomised control trial of adjunctive medroxyprogesterone and tamoxifen in women with mania Author(s) Kulkarni, Jayashri Berk, Michael orcid.org/0000-0002-5554-6946 Wang, Wei orcid.org/0000-0003-4287-1704 Mu, Ling Scarr, Elizabeth Van Rheenen, Tamsyn E. Worsely, Roisin Gurvich, Caroline Gavrilidis, Emorfia de Castella, Anthony Fitzgerald, Paul David, Susan R. Journal name Psychoneuroendocrinology Volume number 43 Start page 52 End page 61 Total pages 10 Publisher Pergamon Place of publication Oxford, England Publication date 2014-05 ISSN 0306-4530 Keyword(s) tamoxifen mania treatment bipolar disorder schizoaffective disorder medroxyprogesterone acetate Summary Emerging research has suggested that hormone treatments such as selective oestrogen receptor modulators (SERMs) or progestins may be useful in the treatment of mania. The current pilot study compared the use of the SERM tamoxifen and the progestin medroxyprogesterone acetate (MPA), as an adjunct to mood stabiliser medications, for the treatment of mania symptoms in 51 women in a 28-day double blind, placebo controlled study. The primary outcome was the change between baseline and day 28 mania scores as measured by the Clinician Administered Rating Scale for Mania (CARS-M). Adjunctive MPA treatment provided greater and more rapid improvement in mania symptoms compared with adjunctive placebo and tamoxifen treatment. Adjunctive therapy with MPA may be a potentially useful new treatment for persistent mania, leading to a greater and more rapid resolution of symptoms compared with mood stabiliser treatment alone. Language eng DOI 10.1016/j.psyneuen.2014.02.004 Field of Research 110399 Clinical Sciences not elsewhere classified Socio Economic Objective 920410 Mental Health HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2014, Elsevier Persistent URL http://hdl.handle.net/10536/DRO/DU:30065229 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 31 Jul 2014, 10:45:21 EST Thu, 31 Jul 2014, 15:48:44 EST Fri, 22 Aug 2014, 10:38:33 EST Fri, 05 Sep 2014, 10:47:10 EST Fri, 17 Oct 2014, 12:49:43 EST Mon, 08 Dec 2014, 08:16:12 EST Filtered Full Citation counts:   Cited 16 times in TR Web of Science Cited 15 times in Scopus Search Google Scholar Access Statistics: 778 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Thu, 31 Jul 2014, 10:44:59 EST by Jane Moschetti

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