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Escitalopram efficacy in depression a cross-ethnicity examination of the serotonin transporter promoter polymorphism

Bousman, Chad A., Sarris, Jerome, Won, Eun-Soo, Chang, Hun-Soo, Singh, Ajeet, Lee, Hwa-Young, Ham, Byung-Joo, Tan, Chay-Hoon, Lee, Min-Soo and Ng, Chee H. 2014, Escitalopram efficacy in depression a cross-ethnicity examination of the serotonin transporter promoter polymorphism, Journal of clinical psychopharmacology, vol. 34, no. 5, pp. 1-4.

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Title Escitalopram efficacy in depression a cross-ethnicity examination of the serotonin transporter promoter polymorphism
Author(s) Bousman, Chad A.
Sarris, Jerome
Won, Eun-Soo
Chang, Hun-Soo
Singh, Ajeet
Lee, Hwa-Young
Ham, Byung-Joo
Tan, Chay-Hoon
Lee, Min-Soo
Ng, Chee H.
Journal name Journal of clinical psychopharmacology
Volume number 34
Issue number 5
Start page 1
End page 4
Total pages 4
Publisher Sage Publications
Place of publication London, England
Publication date 2014-10
ISSN 0269-8811
Keyword(s) antidepressant
genotype
pharmacogenetic
efficacy
Summary Current evidence suggests that polymorphism in the serotonin transporter gene (5-HTTLPR) predicts antidepressant efficacy in whites but less so in Asians. However, it is not clear whether this effect can be observed for specific types of antidepressant drugs. White (n = 47) and Korean (n = 118) participants with major depressive disorder were treated with escitalopram and assessed over 8 weeks. Among those with the l/l but not l/s or s/s genotypes, whites had greater depression score reductions, response rates, and remission rates compared with Koreans. Our results suggest that 5-HTTLPR predicts escitalopram efficacy in an ethnicity-dependent manner.
Language eng
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Sage Publications
Persistent URL http://hdl.handle.net/10536/DRO/DU:30065249

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 31 Jul 2014, 15:02:44 EST by Jane Moschetti

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