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The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis

Samarasinghe, Rasika M., Kanwar, Rupinder K. and Kanwar, Jagat R. 2014, The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis, Biomaterials, vol. 35, no. 26, pp. 7522-7534, doi: 10.1016/j.biomaterials.2014.04.109.

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Title The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis
Author(s) Samarasinghe, Rasika M.ORCID iD for Samarasinghe, Rasika M. orcid.org/0000-0002-3669-0985
Kanwar, Rupinder K.
Kanwar, Jagat R.
Journal name Biomaterials
Volume number 35
Issue number 26
Start page 7522
End page 7534
Total pages 13
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-08
ISSN 0142-9612
Keyword(s) osteoarthritis
nanomedicine
chitosan
lactoferrin
miRNA
iron metabolism
Summary In this study, the therapeutic potentials of 100% iron saturated-bovine lactoferrin encapsulated in alginate-chitosan polymeric nanocarriers (AEC-CP-Fe-bLf-NCs) were examined in in vitro inflammatory OA model and in collagen-induced arthritis (CIA) mice. Oral administration of nanocarriers in mice were non-toxic and significantly induced disease modifying activity by reducing joint inflammation and downregulating the expression of catabolic genes, IL-1β, NO, JNK and MAPK. In addition, up-regulation of type II collagen, aggrecan and inflammation depleted iron and calcium metabolisms via inhibition of miRNA of iron transporting receptors was shown in AEC-CP-Fe-bLf-NCs treated mice.
Language eng
DOI 10.1016/j.biomaterials.2014.04.109
Field of Research 110322 Rheumatology and Arthritis
100709 Nanomedicine
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30065501

Document type: Journal Article
Collection: School of Medicine
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Citation counts: TR Web of Science Citation Count  Cited 23 times in TR Web of Science
Scopus Citation Count Cited 25 times in Scopus
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Created: Fri, 29 Aug 2014, 10:40:10 EST by Rasika Samarasinghe

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