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TMS stimulus-response asymmetry in left- and right handed individuals

Daligadu, Julian, Murphy, Bernadette, Brown, Jeff, Rae, Brendan and Yielder, Paul 2013, TMS stimulus-response asymmetry in left- and right handed individuals, Experimental brain research, vol. 224, no. 3, pp. 411-416, doi: 10.1007/s00221-012-3320-4.

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Title TMS stimulus-response asymmetry in left- and right handed individuals
Author(s) Daligadu, Julian
Murphy, Bernadette
Brown, Jeff
Rae, Brendan
Yielder, Paul
Journal name Experimental brain research
Volume number 224
Issue number 3
Start page 411
End page 416
Total pages 6
Publisher Springer
Place of publication Heidelberg, Germany
Publication date 2013
ISSN 1432-1106
0014-4819
Keyword(s) handedness
transcranial magnetic stimulation
stimulus–response
cortical excitability
plasticity
motor cortex
Summary There have been inconsistencies in the literature regarding asymmetrical neural control and results of experiments using TMS techniques. Therefore, the aim of this study was to further our understanding of the neural relationships that may underlie performance asymmetry with respect to the distal muscles of the hand using a TMS stimulus–response curve technique. Twenty-four male subjects (12 right handed, 12 left handed) participated in a TMS stimulus–response (S–R) curve trial. Focal TMS was applied over the motor cortex to find the optimal position for the first dorsal interossei muscle and to determine rest threshold (RTh). Seven TMS intensities ranging from 90 to 150 % of RTh were delivered in 10 % increments. One single TMS block consisted of 16 stimuli at each intensity. Peak-to-peak amplitudes were measured and the S–R curve generated. In right-handed subjects, the mean difference in slopes between the right and left hand was −0.011 ± 0.03, while the mean difference between hands in left-handed subjects was −0.049 ± 0.08. Left-handed normalized data in right handers displayed a mean of 1.616 ± 1.019 (two-tailed t test p < 0.05). The left-handed group showed a significant change in the normalized slope as indicated by a mean of 1.693 ± 0.149 (two-tailed t test p < 0.00006). The results found in this study reinforce previous work which suggests that there is an asymmetry in neural drive that exists in both left- and right-handed individuals. However, the results show that the non-dominant motor hemisphere displays a greater amount of excitability than the dominant, which goes against the conventional dogma. This asymmetry indicates that the non-dominant hemisphere may have a higher level of excitation or a lower level of inhibition for both groups of participants.
Language eng
DOI 10.1007/s00221-012-3320-4
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30066297

Document type: Journal Article
Collection: School of Health and Social Development
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