You are not logged in.

Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy

Shahidi, A. M., Sampson, G. P., Pritchard, N., Edwards, K., Vagenas, D., Russell, A. W., Malik, R. A. and Efron, N. 2012, Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy, Diabetic medicine, vol. 29, no. 7, pp. 106-111, doi: 10.1111/j.1464-5491.2012.03588.x.

Attached Files
Name Description MIMEType Size Downloads

Title Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy
Author(s) Shahidi, A. M.
Sampson, G. P.
Pritchard, N.
Edwards, K.
Vagenas, D.
Russell, A. W.
Malik, R. A.
Efron, N.
Journal name Diabetic medicine
Volume number 29
Issue number 7
Start page 106
End page 111
Total pages 6
Publisher Wiley-Blackwell
Place of publication Chichester, England
Publication date 2012-07
ISSN 0742-3071
Keyword(s) diabetic peripheral neuropathy
optical coherence tomography
retinal nerve fibre layer thinning
Summary Aims
To investigate the relationship between retinal nerve fibre layer thickness and peripheral neuropathy in patients with Type 2 diabetes, particularly in those who are at higher risk of foot ulceration.

Methods
Global and sectoral retinal nerve fibre layer thicknesses were measured at 3.45 mm diameter around the optic nerve head using optical coherence tomography (OCT). The level of neuropathy was assessed in 106 participants (82 with Type 2 diabetes and 24 healthy controls) using the 0–10 neuropathy disability score. Participants were stratified into four neuropathy groups: none (0–2), mild (3–5), moderate (6–8), and severe (9–10). A neuropathy disability score ‡ 6 was used to define those at higher risk of foot ulceration. Multivariable regression analysis was performed to assess the effect of neuropathy disability scores, age, disease duration and retinopathy on RNFL thickness.

Results
Inferior (but not global or other sectoral) retinal nerve fibre layer thinning was associated with higher neuropathy disability scores (P = 0.03). The retinal nerve fibre layer was significantly thinner for the group with neuropathy disability scores ‡ 6 in the inferior quadrant (P < 0.005). Age, duration of disease and retinopathy levels did not significantly influence retinal nerve fibre layer thickness. Control participants did not show any significant differences in thickness measurements from the group with diabetes and no neuropathy (P > 0.24 for global and all sectors).

Conclusions
Inferior quadrant retinal nerve fibre layer thinning is associated with peripheral neuropathy in patients with Type 2 diabetes, and is more pronounced in those at higher risk of foot ulceration.
Language eng
DOI 10.1111/j.1464-5491.2012.03588.x
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Wiley-Blackwell
Persistent URL http://hdl.handle.net/10536/DRO/DU:30066304

Document type: Journal Article
Collection: School of Health and Social Development
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 30 times in TR Web of Science
Scopus Citation Count Cited 33 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 190 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Thu, 02 Oct 2014, 09:12:18 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.