Cocaine use severity and cerebellar gray matter are associated with reversal learning deficits in cocaine-dependent individuals Moreno-López, Laura, Perales, Jose C., van Son, Dana, Albein-Urios, Natalia, Soriano-Mas, Carles, Martinez-Gonzalez, Jose M., Wiers, Reinout W. and Verdejo-García, Antonio 2015, Cocaine use severity and cerebellar gray matter are associated with reversal learning deficits in cocaine-dependent individuals, Addiction biology, vol. 20, no. 3, pp. 546-556, doi: 10.1111/adb.12143. Attached Files Name Description MIMEType Size Downloads Title Cocaine use severity and cerebellar gray matter are associated with reversal learning deficits in cocaine-dependent individuals Author(s) Moreno-López, Laura Perales, Jose C. van Son, Dana Albein-Urios, Natalia orcid.org/0000-0001-7841-018X Soriano-Mas, Carles Martinez-Gonzalez, Jose M. Wiers, Reinout W. Verdejo-García, Antonio Journal name Addiction biology Volume number 20 Issue number 3 Start page 546 End page 556 Total pages 11 Publisher Wiley Place of publication Chichester, Eng. Publication date 2015-05 ISSN 1369-1600 Keyword(s) cerebellum cocaine inferior frontal gyrus insula reversal learning Summary Cocaine addiction involves persistent deficits to unlearn previously rewarded response options, potentially due to neuroadaptations in learning-sensitive regions. Cocaine-targeted prefrontal systems have been consistently associated with reinforcement learning and reversal deficits, but more recent interspecies research has raised awareness about the contribution of the cerebellum to cocaine addiction and reversal. We aimed at investigating the link between cocaine use, reversal learning and prefrontal, insula and cerebellar gray matter in cocaine-dependent individuals (CDIs) varying on levels of cocaine exposure in comparison with healthy controls (HCs). Twenty CDIs and 21 HCs performed a probabilistic reversal learning task (PRLT) and were subsequently scanned in a 3-Tesla magnetic resonance imaging scanner. In the PRLT, subjects progressively learn to respond to one predominantly reinforced stimulus, and thenmust learn to respond according to the opposite, previously irrelevant, stimulus-reward pairing. Performance measureswere errors after reversal (reversal cost), and probability of maintaining response after errors. Voxel-based morphometry was conducted to investigate the association between gray matter volume in the regions of interest and cocaine use and PRLT performance. Severity of cocaine use correlated with gray matter volume reduction in the left cerebellum (lobule VIII), while greater reversal cost was correlated with gray matter volume reduction in a partially overlapping cluster (lobules VIIb and VIII). Right insula/inferior frontal gyrus correlated with probability of maintaining response after errors. Severity of cocaine use detrimentally impacted reversal learning and cerebellar gray matter. Language eng DOI 10.1111/adb.12143 Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2014, Society for the Study of Addiction Persistent URL http://hdl.handle.net/10536/DRO/DU:30066320 Document type: Journal Article Collections: Faculty of Health School of Psychology Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 02 Oct 2014, 09:18:22 EST Fri, 03 Oct 2014, 12:41:12 EST Fri, 05 Dec 2014, 13:04:40 EST Wed, 04 Feb 2015, 11:28:28 EST Tue, 04 Aug 2015, 14:16:17 EST Tue, 04 Aug 2015, 14:19:00 EST Tue, 11 Aug 2015, 11:11:21 EST Fri, 23 Sep 2016, 15:52:21 EST Sat, 03 Jun 2017, 02:31:50 EST Filtered Full Citation counts:   Cited 21 times in TR Web of Science Cited 23 times in Scopus Search Google Scholar Access Statistics: 468 Abstract Views, 9 File Downloads  -  Detailed Statistics Created: Thu, 02 Oct 2014, 09:18:22 EST

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