Corneal markers of diabetic neuropathy

Pritchard, Nicola, Edwards, Katie, Shahidi, Ayda M., Sampson, Geoff P., Russell, Anthony W., Malik, Rayaz A. and Efron, Nathan 2011, Corneal markers of diabetic neuropathy, Ocular surface, vol. 9, no. 1, pp. 17-28, doi: 10.1016/S1542-0124(11)70006-4.

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Title Corneal markers of diabetic neuropathy
Author(s) Pritchard, Nicola
Edwards, Katie
Shahidi, Ayda M.
Sampson, Geoff P.ORCID iD for Sampson, Geoff P.
Russell, Anthony W.
Malik, Rayaz A.
Efron, Nathan
Journal name Ocular surface
Volume number 9
Issue number 1
Start page 17
End page 28
Total pages 12
Publisher Elsevier
Place of publication Philadelphia, PA
Publication date 2011-01
ISSN 1542-0124
Keyword(s) corneal confocal microscopy
corneal markers
corneal nerves
corneal sensitivity
diabetic neuropathy
noncontact corneal esthesiometry
Summary Diabetic neuropathy is a significant clinical problem that currently has no effective therapy, and in advanced cases, leads to foot ulceration and lower limb amputation. The accurate detection, characterization and quantification of this condition are important in order to define at-risk patients, anticipate deterioration, monitor progression, and assess new therapies. This review evaluates novel corneal methods of assessing diabetic neuropathy. Two new noninvasive corneal markers have emerged, and in cross-sectional studies have demonstrated their ability to stratify the severity of this disease. Corneal confocal microscopy allows quantification of corneal nerve parameters and noncontact corneal esthesiometry, the functional correlate of corneal structure, assesses the sensitivity of the cornea. Both these techniques are quick to perform, produce little or no discomfort for the patient, and are suitable for clinical settings. Each has advantages and disadvantages over traditional techniques for assessing diabetic neuropathy. Application of these new corneal markers for longitudinal evaluation of diabetic neuropathy has the potential to reduce dependence on more invasive, costly, and time-consuming assessments, such as skin biopsy.
Language eng
DOI 10.1016/S1542-0124(11)70006-4
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Elsevier
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Document type: Journal Article
Collection: School of Health and Social Development
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