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Improvements in insulin resistance with exercise training: a lipocentric approach

Bruce, Clinton R. and Hawley, John A. 2004, Improvements in insulin resistance with exercise training: a lipocentric approach, Medicine and science in sports and exercise, vol. 36, no. 7, pp. 1196-1201.

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Title Improvements in insulin resistance with exercise training: a lipocentric approach
Author(s) Bruce, Clinton R.ORCID iD for Bruce, Clinton R. orcid.org/0000-0002-0515-3343
Hawley, John A.
Journal name Medicine and science in sports and exercise
Volume number 36
Issue number 7
Start page 1196
End page 1201
Total pages 6
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, PA
Publication date 2004
ISSN 0195-9131
1530-0315
Keyword(s) Endurance training
Type 2 diabetes
Obesity
Intramuscular triglyceride
Long chain fatty ACYL COA
Skeletal muscle oxidative capacity
Summary Traditional views on the metabolic derangements underlying insulin resistance and Type 2 diabetes have been largely “glucocentric” in nature, focusing on the hyperglycemic and/or hyperinsulinemic states that result from impaired glucose tolerance. But in addition to glucose intolerance, there is a coordinated breakdown in lipid dynamics in individuals with insulin resistance, manifested by elevated levels of circulating free fatty acids, diminished rates of lipid oxidation, and excess lipid accumulation in skeletal muscle and/or liver. This review examines the premise that an oversupply and/or accumulation of lipid directly inhibits insulin action on glucose metabolism via changes at the level of substrate competition, enzyme regulation, intracellular signaling, and/or gene transcription. If a breakdown in lipid dynamics is causal in the development of insulin resistance (rather than a coincidental feature resulting from it), it should be possible to demonstrate that interventions that improve lipid homeostasis cause reciprocal changes in insulin sensitivity. Accordingly, the efficacy of aerobic endurance training in human subjects in mediating the association between deranged lipid metabolism and insulin resistance will be examined. It will be demonstrated that aerobic exercise training is a potent and effective primary intervention strategy in the prevention and treatment of individuals with insulin resistance.
Notes This paper was originally presented at the Symposium-Preventing Insulin Resisance through Exercise: A Cellular Approach
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067059

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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