Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle

Turner, Nigel, Lee, Jong Sam, Bruce, Clinton R., Mitchell, Todd W., Else, Paul L., Hulbert, A. J. and Hawley, John A. 2004, Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle, Journal of applied physiology, vol. 96, no. 3, pp. 974-980, doi: 10.1152/japplphysiol.01003.2003.

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Title Greater effect of diet than exercise training on the fatty acid profile of rat skeletal muscle
Author(s) Turner, Nigel
Lee, Jong Sam
Bruce, Clinton R.ORCID iD for Bruce, Clinton R. orcid.org/0000-0002-0515-3343
Mitchell, Todd W.
Else, Paul L.
Hulbert, A. J.
Hawley, John A.
Journal name Journal of applied physiology
Volume number 96
Issue number 3
Start page 974
End page 980
Total pages 7
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2004
ISSN 8750-7587
1522-1601
Keyword(s) Dietary fat
Insulin sensitivity
Phospholipids
Training
Summary We determined the interaction of diet and exercise-training intensity on membrane phospholipid fatty acid (FA) composition in skeletal muscle from 36 female Sprague-Dawley rats. Animals were randomly divided into one of two dietary conditions: high-carbohydrate (64.0% carbohydrate by energy, n = 18) or high fat (78.1% fat by energy, n = 18). Rats in each diet condition were then allocated to one of three subgroups: control, which performed no exercise training; low-intensity (8 m/min) treadmill run training; or high-intensity (28 m/min) run training. All exercise-trained rats ran 1,000 m/session, 4 days/wk for 8 wk and were killed 48 h after the last training bout. Membrane phospholipids were extracted, and FA composition was determined in the red and white vastus lateralis muscles, Diet exerted a major influence on phospholipid FA composition, with the high-fat diet being associated with a significantly (P < 0.01) elevated ratio of n-6/n-3 FA for both red (2.7-3.2 vs. 1.0-1.1) and white vastus lateralis muscle (2.5-2.9 vs. 1.2). In contrast, alterations in FA composition as a result of either exercise-training protocol were only minor in comparison. We conclude that, under the present experimental conditions, a change in the macronutrient content of the diet was a more potent modulator of skeletal muscle membrane phospholipid FA composition compared with either low- or high-intensity treadmill exercise training.
Language eng
DOI 10.1152/japplphysiol.01003.2003
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067061

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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