Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes

Bruce, C. R., Kriketos, A. D., Cooney, G. J. and Hawley, J. A. 2004, Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes, Diabetologia, vol. 47, no. 1, pp. 23-30, doi: 10.1007/s00125-003-1265-7.

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Title Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes
Author(s) Bruce, C. R.ORCID iD for Bruce, C. R. orcid.org/0000-0002-0515-3343
Kriketos, A. D.
Cooney, G. J.
Hawley, J. A.
Journal name Diabetologia
Volume number 47
Issue number 1
Start page 23
End page 30
Total pages 8
Publisher Springer-Verlag
Place of publication Heidelberg, Germany
Publication date 2004
ISSN 0012-186X
1432-0428
Keyword(s) Insulin resistance
Long-chain fatty acyl CoA
Muscle triacylglycerol
Oxidative capacity
Summary Aim/hypothesis. We determined the effect of exercise training on insulin sensitivity and muscle lipids (triglyceride [TGm] and long-chain fatty acyl CoA [LCACoA] concentration) in patients with Type 2 diabetes. Methods. Seven patients with Type 2 diabetes and six healthy control subjects who were matched for age, BMI, % body fat and VO2peak participated in a 3 days per week training program for 8 weeks. Insulin sensitivity was determined pre- and post-training during a 120 min euglycaemic- hyperinsulinaemic clamp and muscle biopsies were obtained before and after each clamp. Oxidative enzyme activities [citrate synthase (CS), β-hydroxy-acyl- CoA (β-HAD)] and TGm were determined from basal muscle samples pre- and post training, while total LCACoA content was measured in samples obtained before and after insulin-stimulation, pre- and post training. Results. The training-induced increase in VO2peak (∼20%, p<0.01) was similar in both groups. Compared with control subjects, insulin sensitivity was lower in the diabetic patients before and after training (∼60%; p<0.05), but was increased to the same extent in both groups with training (∼30%; p<0.01). TGm was increased in patients with Type 2 diabetes (170%; p<0.05) before, but was normalized to levels observed in control subjects after training. Basal LCACoA content was similar between groups and was unaltered by training. Insulin-stimulation had no detectable effect on LCACoA content. CS and β-HAD activity were increased to the same extent in both groups in response to training (p<0.001). Conclusion/interpretation. We conclude that the enhanced insulin sensitivity observed after short-term exercise training was associated with a marked decrease in TGm content in patients with Type 2 diabetes. However, despite the normalization of TGm to levels observed in healthy individuals, insulin resistance was not completely reversed in the diabetic patients.
Language eng
DOI 10.1007/s00125-003-1265-7
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067062

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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