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Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats

Bruce, Clinton R., Lee, Jong Sam and Hawley, John A. 2001, Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats, Journal of applied physiology, vol. 91, no. 4, pp. 1512-1519.

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Title Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats
Author(s) Bruce, Clinton R.ORCID iD for Bruce, Clinton R. orcid.org/0000-0002-0515-3343
Lee, Jong Sam
Hawley, John A.
Journal name Journal of applied physiology
Volume number 91
Issue number 4
Start page 1512
End page 1519
Total pages 8
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2001
ISSN 8750-7587
1522-1601
Keyword(s) GLUT-4
Glycogen synthase
Hexokinase
Insulin resistance
Summary We determined the effect of an acute bout of swimming (8 × 30 min) followed by either carbohydrate administration (0.5 mg/g glucose ip and ad libitum access to chow; CHO) or fasting (Fast) on postexercise glycogen resynthesis in soleus muscle and liver from female lean (ZL) and obese insulin-resistant (ZO) Zucker rats. Resting soleus muscle glycogen concentration ([glycogen]) was similar between genotypes and was reduced by 73 (ZL) and 63% (ZO) after exercise (P < 0.05). Liver [glycogen] at rest was greater in ZO than ZL (334 ± 31 vs. 247 ± 16 μmol/g wet wt; P < 0.01) and fell by 44 and 94% after exercise (P < 0.05). The fractional activity of glycogen synthase (active/total) increased immediately after exercise (from 0.22 ± 0.05 and 0.32 ± 0.04 to 0.63 ± 0.08 vs. 0.57 ± 0.05; P < 0.01 for ZL and ZO rats, respectively) and remained elevated above resting values after 30 min of recovery. During this time, muscle [glycogen] in ZO increased 68% with CHO (P < 0.05) but did not change in Fast. Muscle [glycogen] was unchanged in ZL from postexercise values after both treatments. After 6 h recovery, GLUT-4 protein concentration was increased above resting levels by a similar extent for both genotypes in both fasted (∼45%) and CHO-supplemented (∼115%) rats. Accordingly, during this time CHO refeeding resulted in supercompensation in both genotypes (68% vs. 44% for ZL and ZO). With CHO, liver [glycogen] was restored to resting levels in ZL but remained at postexercise values for ZO after both treatments. We conclude that the increased glucose availability with carbohydrate refeeding after glycogen-depleting exercise resulted in glycogen supercompensation, even in the face of muscle insulin-resistance.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067067

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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