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Assessing regional cerebral blood flow in depression using 320-slice computed tomography

Wang, Yiming, Zhang, Hongming, Tang, Songlin, Liu, Xingde, O'Neil, Adrienne, Turner, Alyna, Chai, Fangxian, Chen, Fanying and Berk, Michael 2014, Assessing regional cerebral blood flow in depression using 320-slice computed tomography, PLoS One, vol. 9, no. 9, pp. 1-10, doi: 10.1371/journal.pone.0107735.

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Title Assessing regional cerebral blood flow in depression using 320-slice computed tomography
Author(s) Wang, Yiming
Zhang, Hongming
Tang, Songlin
Liu, Xingde
O'Neil, Adrienne
Turner, Alyna
Chai, Fangxian
Chen, Fanying
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name PLoS One
Volume number 9
Issue number 9
Article ID e107735
Start page 1
End page 10
Total pages 10
Publisher PLoS
Place of publication San Francisco, Cal.
Publication date 2014-09-24
ISSN 1932-6203
Keyword(s) science & technology
multidisciplinary sciences
science & technology - other topics
late-life depression
major depression
electroconvulsive-therapy
magnetic-resonance
HMPAO Spect
CT
antidepressant
brain
disorder
disease
Summary While there is evidence that the development and course of major depressive disorder (MDD) symptomatology is associated with vascular disease, and that there are changes in energy utilization in the disorder, the extent to which cerebral blood flow is changed in this condition is not clear. This study utilized a novel imaging technique previously used in coronary and stroke patients, 320-slice Computed-Tomography (CT), to assess regional cerebral blood flow (rCBF) in those with MDD and examine the pattern of regional cerebral perfusion. Thirty nine participants with depressive symptoms (Hamilton Depression Rating Scale 24 (HAMD24) score >20, and Self-Rating Depression Scale (SDS) score >53) and 41 healthy volunteers were studied. For all subjects, 3 ml of venous blood was collected to assess hematological parameters. Trancranial Doppler (TCD) ultrasound was utilized to measure parameters of cerebral artery rCBFV and analyse the Pulsatility Index (PI). 16 subjects (8 =  MDD; 8 =  healthy) also had rCBF measured in different cerebral artery regions using 320-slice CT. Differences among groups were analyzed using ANOVA and Pearson's tests were employed in our statistical analyses. Compared with the control group, whole blood viscosity (including high\middle\low shear rate)and hematocrit (HCT) were significantly increased in the MDD group. PI values in different cerebral artery regions and parameters of rCBFV in the cerebral arteries were decreased in depressive participants, and there was a positive relationship between rCBFV and the corresponding vascular rCBF in both gray and white matter. rCBF of the left gray matter was lower than that of the right in MDD. Major depression is characterized by a wide range of CBF impairments and prominent changes in gray matter blood flow. 320-slice CT appears to be a valid and promising tool for measuring rCBF, and could thus be employed in psychiatric settings for biomarker and treatment response purposes.
Language eng
DOI 10.1371/journal.pone.0107735
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID NHMRC 1059660
Copyright notice ©2014, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067187

Document type: Journal Article
Collections: School of Medicine
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Created: Mon, 08 Dec 2014, 10:22:50 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.