Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass

Davis, J., Maes, M., Andreazza, A., McGrath, J.J., Tye, S.J. and Berk, M. 2015, Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass, Molecular psychiatry, vol. 20, pp. 152-153, doi: 10.1038/mp.2014.139.

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Title Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass
Author(s) Davis, J.
Maes, M.
Andreazza, A.
McGrath, J.J.
Tye, S.J.
Berk, M.ORCID iD for Berk, M.
Journal name Molecular psychiatry
Volume number 20
Start page 152
End page 153
Total pages 2
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2015
ISSN 1476-5578
Summary There is currently considerable imprecision in the nosology of biomarkers used in the study of neuropsychiatric disease. The neuropsychiatric field lags behind others such as oncology, wherein, rather than using 'biomarker' as a blanket term for a diverse range of clinical phenomena, biomarkers have been actively classified into separate categories, including prognostic and predictive tests. A similar taxonomy is proposed for neuropsychiatric diseases in which the core biology remains relatively unknown. This paper divides potential biomarkers into those of (1) risk, (2) diagnosis/trait, (3) state or acuity, (4) stage, (5) treatment response and (6) prognosis, and provides illustrative exemplars. Of course, biomarkers rely on available technology and, as we learn more about the neurobiological correlates of neuropsychiatric disorders, we will realize that the classification of biomarkers across these six categories can change, and some markers may fit into more than one category.Molecular Psychiatry advance online publication, 28 October 2014; doi:10.1038/mp.2014.139.
Language eng
DOI 10.1038/mp.2014.139
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
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Document type: Journal Article
Collections: Faculty of Health
School of Psychology
School of Medicine
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