Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis

Kim,SW, Schäfer,MR, Klier,CM, Berk,M, Rice,S, Allott,K, Bartholomeusz,CF, Whittle,SL, Pilioussis,E, Pantelis,C, McGorry,PD and Amminger,GP 2014, Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis, Schizophrenia Research, vol. 158, no. 1-3, pp. 39-44, doi: 10.1016/j.schres.2014.06.032.

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Title Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis
Author(s) Kim,SW
Schäfer,MR
Klier,CM
Berk,MORCID iD for Berk,M orcid.org/0000-0002-5554-6946
Rice,S
Allott,K
Bartholomeusz,CF
Whittle,SL
Pilioussis,E
Pantelis,C
McGorry,PD
Amminger,GP
Journal name Schizophrenia Research
Volume number 158
Issue number 1-3
Start page 39
End page 44
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-09
ISSN 1573-2509
0920-9964
Keyword(s) Cognitive symptom
Eicosenoic acid
Intracranial area
Membrane fatty acid
Schizophrenia
Ultra-high risk
Science & Technology
Life Sciences & Biomedicine
Psychiatry
ESTIMATING INTRACRANIAL VOLUME
RANDOMIZED CONTROLLED-TRIAL
SYNDROME SCALE PANSS
1ST-EPISODE PSYCHOSIS
INDICATED PREVENTION
METAANALYSIS
DEFICITS
ONSET
RATS
Summary Cognitive symptoms and impairment are central to schizophrenia and often an early sign of this condition. The present study investigated biological correlates of cognitive symptoms and performance in individuals at ultra-high risk (UHR) for psychosis. The study sample comprised 80 neuroleptic-naïve UHR individuals aged 13-25 years. Associations among erythrocyte membrane fatty acid levels, measured by gas chromatography, and cognitive functioning were investigated in UHR patients. Subjects were divided into terciles based on their scores on the cognitive factor of the Positive and Negative Syndrome Scale. The Zahlen-Verbindungs Test (ZVT) (the number-combination test) was also used as a measure of information-processing speed. Exploratory analysis was conducted to investigate the relationship between membrane fatty acid levels with the size of the intracranial area (ICA), a neurodevelopmental measure relevant to schizophrenia, in half of subjects (n=40) using magnetic resonance imaging. The adjusted analysis revealed that omega-9 eicosenoic and erucic acid levels were significantly higher, but omega-3 docosahexaenoic acid levels were significantly lower, in the cognitively impaired than in the cognitively intact group. We found a significant negative association of eicosenoic, erucic, and gamma-linoleic acids with ZVT scores. A negative association between ICA and membrane levels of eicosenoic acid was also found. This is the first study to demonstrate the relationship between membrane fatty acids and cognitive function in neuroleptic-naïve subjects at UHR for psychosis. The study findings indicate that abnormalities in membrane fatty acids may be associated with the neurodevelopmental disruption associated with the cognitive impairments of individuals at UHR for psychosis.
Language eng
DOI 10.1016/j.schres.2014.06.032
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067191

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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