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SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study.

Pizzo de Castro, Márcia Regina, Maes, Michael, Guembarovski, Roberta Losi, Ariza, Carolina Batista, Reiche, Edna Maria Vissoci, Vargas, Heber Odebrecht, Vargas, Mateus Medonça, de Melo, Luiz Gustavo Piccoli, Dodd, Seetal, Berk, Michael, Watanabe, Maria Angelica Ehara and Nunes, Sandra Odebrecht 2014, SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study., BMC Genetics, vol. 15, no. Article number 78-1, doi: 10.1186/1471-2156-15-78.

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Title SLC6A4 STin2 VNTR genetic polymorphism is associated with tobacco use disorder, but not with successful smoking cessation or smoking characteristics: a case control study.
Author(s) Pizzo de Castro, Márcia Regina
Maes, Michael
Guembarovski, Roberta Losi
Ariza, Carolina Batista
Reiche, Edna Maria Vissoci
Vargas, Heber Odebrecht
Vargas, Mateus Medonça
de Melo, Luiz Gustavo Piccoli
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Watanabe, Maria Angelica Ehara
Nunes, Sandra Odebrecht
Journal name BMC Genetics
Volume number 15
Issue number Article number 78
End page 1
Total pages 9
Publisher 9
Place of publication London, England
Publication date 2014-06
ISSN 1471-2156
Keyword(s) Genetic
Inflammation
Oxidative stress
Polymorphism
Serotonin
STin2 VNTR
Genetic
Smoking cessation
Tobacco use disorder
Summary The aim of this study was to determine if variable number of tandem repeats (VNTR) in the second intron (STin2) of the serotonin transporter (SLC6A4) gene was associated with tobacco use disorder, successful smoking cessation, or smoking characteristics. In this case-control study, patients with current tobacco use disorder, diagnosed according to DSM IV criteria (n = 185), and never-smokers, diagnosed according to CDC criteria (n = 175), were recruited and received 52 weeks of combined pharmacotherapy and cognitive therapy. Successful smoking cessation was defined as exhaled carbon monoxide < 6 ppm. SLC6A4 gene STin2 VNTR polymorphism was assessed using a Multiplex-PCR-based method. At baseline, participants were evaluated using the Fagerström Test for Nicotine Dependence (FTND) and the ASSIST scale.
Language eng
DOI 10.1186/1471-2156-15-78
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Biomed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067212

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.