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Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications

Morris, Gerwyn, Anderson, George, Berk, Michael and Maes, Michael 2013, Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications, Molecular neurobiology, vol. 48, no. 3, pp. 883-903, doi: 10.1007/s12035-013-8477-8.

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Title Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications
Author(s) Morris, Gerwyn
Anderson, George
Berk, Michael
Maes, Michael
Journal name Molecular neurobiology
Volume number 48
Issue number 3
Start page 883
End page 903
Total pages 21
Publisher Springer
Place of publication New York, N.Y.
Publication date 2013-12
ISSN 1559-1182
Keyword(s) Humans
Mental Disorders
Nitrosation
Oxidative Stress
Signal Transduction
Ubiquinone
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Coenzyme Q10
Oxidative and nitrosative stress
Inflammation
Cytokines
Mitochondria
Summary Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate. It additionally regulates gene expression and apoptosis; is an essential cofactor of uncoupling proteins; and has anti-inflammatory, redox modulatory, and neuroprotective effects. This paper reviews the known physiological role of CoQ10 in cellular metabolism, cell death, differentiation and gene regulation, and examines the potential repercussions of CoQ10 depletion including its role in illnesses such as Parkinson's disease, depression, myalgic encephalomyelitis/chronic fatigue syndrome, and fibromyalgia. CoQ10 depletion may play a role in the pathophysiology of these disorders by modulating cellular processes including hydrogen peroxide formation, gene regulation, cytoprotection, bioenegetic performance, and regulation of cellular metabolism. CoQ10 treatment improves quality of life in patients with Parkinson's disease and may play a role in delaying the progression of that disorder. Administration of CoQ10 has antidepressive effects. CoQ10 treatment significantly reduces fatigue and improves ergonomic performance during exercise and thus may have potential in alleviating the exercise intolerance and exhaustion displayed by people with myalgic encepholamyletis/chronic fatigue syndrome. Administration of CoQ10 improves hyperalgesia and quality of life in patients with fibromyalgia. The evidence base for the effectiveness of treatment with CoQ10 may be explained via its ability to ameliorate oxidative stress and protect mitochondria.
Language eng
DOI 10.1007/s12035-013-8477-8
Field of Research 110319 Psychiatry (incl Psychotherapy)
111714 Mental Health
1109 Neurosciences
1702 Cognitive Science
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Springer Science+Business Media New York
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067215

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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