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To a broader concept of remission: rating the health-related quality of life in bipolar disorder

Subero, Marta Martin, Berk, Lesley, Dodd, Seetal, Kulkarni, Jayashri, De Castella, Anthony, Fitzgerald, Paul B. and Berk, Michael 2013, To a broader concept of remission: rating the health-related quality of life in bipolar disorder, Journal of affective disorders, vol. 150, no. 2, pp. 673-676, doi: 10.1016/j.jad.2013.03.023.

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Title To a broader concept of remission: rating the health-related quality of life in bipolar disorder
Author(s) Subero, Marta Martin
Berk, LesleyORCID iD for Berk, Lesley orcid.org/0000-0002-3677-7503
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Kulkarni, Jayashri
De Castella, Anthony
Fitzgerald, Paul B.
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Journal of affective disorders
Volume number 150
Issue number 2
Start page 673
End page 676
Total pages 4
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-09-05
ISSN 1573-2517
Keyword(s) Bipolar disorder
CGI
EQ-5D
Health-related quality of life
Remission
SF-36
Adult
Female
Health Surveys
Humans
Male
Middle Aged
Prospective Studies
Psychiatric Status Rating Scales
Psychotic Disorders
Quality of Life
Reference Values
Treatment Outcome
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Psychiatry
Neurosciences & Neurology
Summary BACKGROUND: The relationship between remission and quality of life in bipolar disorder is incompletely understood. This study aimed to determine cut-points on the 36-item Short-Form Health Survey (SF-36) and the European Quality of Life Index (EQ-5D) that corresponded with an objective clinical measure of remission in bipolar disorder patients.
METHODS: Data from a 2-year prospective observational study of bipolar and schizoaffective patients were analysed. Concordant with previous research, the Clinical Global Impression-Bipolar Version (CGI-BP) was used as an index of remission, specifically the severity scores of 1 (normal, not at all ill) and 2 (borderline mentally ill). The mean SF-36 standardized mental component (SMC) and standardized physical component (SPC) total scores as well as the EQ-5D index score that corresponded with a CGI-BP severity score of 1 or 2 were determined.
RESULTS: The mean SF-36 score that corresponded with a CGI-BP severity score of 1 or 2, was below 50 for the SPC (49.3) and below 49 for the SMC (48.3). The mean EQ-5D score that corresponded with a CGI-BP severity score of 1 or 2 was below 0.88 (0.87).
LIMITATIONS: Although the initial sample is sufficiently large (n=240), 49 patients scored 1 and 2 on the CGI-S, of which 12 had schizoaffective disorder.
CONCLUSIONS: This study suggests that a cut-off score of ≥50 for the SPC and ≥49 for the SMC of the SF-36 and ≥0.88 for the EQ-5D index approximates a CGI-BP definition of remission.
Language eng
DOI 10.1016/j.jad.2013.03.023
Field of Research 110319 Psychiatry (incl Psychotherapy)
111714 Mental Health
Socio Economic Objective 920410 Mental Health
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2013, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067217

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
School of Medicine
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