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Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease.

van Langenberg, DR, Della Gatta, Paul, Hill, Briony, Zacharewicz, Evelyn, Gibson, PR and Russell, Aaron 2014, Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease., Journal of Crohn's and Colitis, vol. 8, no. 7, pp. 626-634, doi: 10.1016/j.crohns.2013.11.024.

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Title Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease.
Author(s) van Langenberg, DR
Della Gatta, PaulORCID iD for Della Gatta, Paul orcid.org/0000-0003-4993-3963
Hill, Briony
Zacharewicz, Evelyn
Gibson, PRORCID iD for Gibson, PR orcid.org/0000-0002-7323-9501
Russell, Aaron
Journal name Journal of Crohn's and Colitis
Volume number 8
Issue number 7
Start page 626
End page 634
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-07-01
ISSN 1876-4479
Keyword(s) disability
inflammatory bowel disease
muscle atrophy
sarcopenia
vitamin d
science & technology
life sciences & biomedicine
gastroenterology & hepatology
foxo transcription factors
necrosis-factor-alpha
clinical remission
ubiqitin ligases
older women
atrophy
strength
AKT
Interleukin-6
hypertrophy
UBIQUITIN LIGASES
Summary In Crohn's disease (CD), skeletal muscle mass and function are reduced compared to healthy controls, potentially resulting in disability. Mechanisms contributing to muscle impairment, and thus potential therapeutic targets, are poorly understood. This study aimed to measure and compare skeletal muscle size and molecular targets involved in skeletal muscle growth, in CD subjects and healthy controls.
Language eng
DOI 10.1016/j.crohns.2013.11.024
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
1103 Clinical Sciences
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067264

Document type: Journal Article
Collections: School of Psychology
School of Exercise and Nutrition Sciences
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Citation counts: TR Web of Science Citation Count  Cited 16 times in TR Web of Science
Scopus Citation Count Cited 21 times in Scopus
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Created: Mon, 08 Dec 2014, 10:02:08 EST

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