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Effect of exercise training on skeletal muscle cytokine expression in the elderly.

Della Gatta, Paul, Garnham, Andrew, Peake, JM and Cameron-Smith, D 2014, Effect of exercise training on skeletal muscle cytokine expression in the elderly., Brain, Behavior, and Immunity, vol. 39, pp. 80-86, doi: 10.1016/j.bbi.2014.01.006.

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Title Effect of exercise training on skeletal muscle cytokine expression in the elderly.
Author(s) Della Gatta, Paul
Garnham, Andrew
Peake, JM
Cameron-Smith, D
Journal name Brain, Behavior, and Immunity
Volume number 39
Start page 80
End page 86
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-07
ISSN 1090-2139
Keyword(s) aging
chemokine
hypertrophy
inflammation
myokine
sarcopenia
strength
science & technology
life sciences & biomedicine
immunology
neurosciences
neurosciences & neurology
necrosis-factor-alpha
resistance exercise
gene-expression
humans
mass
age
activation
health
growth
Summary Aging is associated with increased circulating pro-inflammatory and lower anti-inflammatory cytokines. Exercise training, in addition to improving muscle function, reduces these circulating pro-inflammatory cytokines. Yet, few studies have evaluated changes in the expression of cytokines within skeletal muscle after exercise training. The aim of the current study was to examine the expression of cytokines both at rest and following a bout of isokinetic exercise performed before and after 12weeks of resistance exercise training in young (n=8, 20.3±0.8yr) and elderly men (n=8, 66.9±1.6yr). Protein expression of various cytokines was determined in muscle homogenates. The expression of MCP-1, IL-8 and IL-6 (which are traditionally classified as 'pro-inflammatory') increased substantially after acute exercise. By contrast, the expression of the anti-inflammatory cytokines IL-4, IL-10 and IL-13 increased only slightly (or not at all) after acute exercise. These responses were not significantly different between young and elderly men, either before or after 12weeks of exercise training. However, compared with the young men, the expression of pro-inflammatory cytokines 2h post exercise tended to be greater in the elderly men prior to training. Training attenuated this difference. These data suggest that the inflammatory response to unaccustomed exercise increases with age. Furthermore, regular exercise training may help to normalize this inflammatory response, which could have important implications for muscle regeneration and adaptation in the elderly.
Language eng
DOI 10.1016/j.bbi.2014.01.006
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
1107 Immunology
1109 Neurosciences
1701 Psychology
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067273

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