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Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury

Williams, David, Venardos, Kylie M., Byrne, Melissa, Joshi, Mandar, Horlock, Duncan, Lam, Nicholas T., Gregorevic, Paul, McGee, Sean L. and Kaye, David M. 2014, Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury, PLoS one, vol. 9, no. 8, Article number : e104643, pp. 1-11, doi: 10.1371/journal.pone.0104643.

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Title Abnormal mitochondrial L-arginine transport contributes to the pathogenesis of heart failure and rexoygenation injury
Author(s) Williams, David
Venardos, Kylie M.
Byrne, Melissa
Joshi, Mandar
Horlock, Duncan
Lam, Nicholas T.
Gregorevic, Paul
McGee, Sean L.
Kaye, David M.
Journal name PLoS one
Volume number 9
Issue number 8
Season Article number : e104643
Start page 1
End page 11
Total pages 11
Publisher Public Library of Science
Place of publication San Francisco, CA
Publication date 2014-08-11
ISSN 1932-6203
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
NITRIC-OXIDE SYNTHASE
ISCHEMIA-REPERFUSION INJURY
ISOLATED CARDIAC MITOCHONDRIA
MYOCARDIAL-ISCHEMIA
COMPLEX-I
ENDOTHELIAL-CELLS
METABOLIC STATES
AMINO-ACIDS
MODULATION
BIOGENESIS
Summary Impaired mitochondrial function is fundamental feature of heart failure (HF) and myocardial ischemia. In addition to the effects of heightened oxidative stress, altered nitric oxide (NO) metabolism, generated by a mitochondrial NO synthase, has also been proposed to impact upon mitochondrial function. However, the mechanism responsible for arginine transport into mitochondria and the effect of HF on such a process is unknown. We therefore aimed to characterize mitochondrial L-arginine transport and to investigate the hypothesis that impaired mitochondrial L-arginine transport plays a key role in the pathogenesis of heart failure and myocardial injury.
Language eng
DOI 10.1371/journal.pone.0104643
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Public Library of Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067306

Document type: Journal Article
Collections: School of Medicine
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Created: Mon, 08 Dec 2014, 14:29:46 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.