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MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells

Guller, Isabelle 2014, MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells, Doctor of Philosophy thesis, School of Exercise and Nutrition Sciences, Deakin University.

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Title MicroRNA profiling in brown adipose tissue and muscle-derived CD34+ cells
Author Guller, Isabelle
Institution Deakin University
School School of Exercise and Nutrition Sciences
Faculty Faculty of Health
Degree type Research doctorate
Degree name Doctor of Philosophy
Thesis advisor Russell, Aaron
Wadley, GlennORCID iD for Wadley, Glenn orcid.org/0000-0002-6617-4359
Date submitted 2014-04-03
Keyword(s) obesity
lipids
brown adipose tissue
Summary  The major findings established a mouse brown adipose tissue (BAT)-enriched miRNA profile conserved in human BAT and predicted to target genes potentially involved in growth and development. The present results also identified a human skeletal muscle-derived CD34+ cell population with the capacity to differentiate into brown adipocytes in vitro. These CD34+ expressed common miRNAs to mouse and human BAT. Finally these findings show an up-regulation of 4 miRNAs in human adult skeletal muscle following cold exposure. These miRNAs were also present in mouse and human BAT as well as in CD34+ brown adipocytes.
Language eng
Field of Research 060103 Cell Development, Proliferation and Death
060699 Physiology not elsewhere classified
Socio Economic Objective 920106 Endocrine Organs and Diseases (excl. Diabetes)
Description of original 143 pp.
Copyright notice ┬ęThe author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067323

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.