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Cancer stem cells: a contentious hypothesis now moving forward

O'Connor, Michael L., Xiang, Dongxi, Shigdar, Sarah, Macdonald, Joanna, Li, Yong, Wang, Tao, Pu, Chunwen, Wang, Zhidong, Qiao, Liang and Duan, Wei 2014, Cancer stem cells: a contentious hypothesis now moving forward, Cancer letters, vol. 344, no. 2, pp. 180-187, doi: 10.1016/j.canlet.2013.11.012.

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Title Cancer stem cells: a contentious hypothesis now moving forward
Author(s) O'Connor, Michael L.
Xiang, Dongxi
Shigdar, Sarah
Macdonald, Joanna
Li, Yong
Wang, Tao
Pu, Chunwen
Wang, Zhidong
Qiao, Liang
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Journal name Cancer letters
Volume number 344
Issue number 2
Start page 180
End page 187
Publisher Elsevier Ireland
Place of publication Shannon, Ireland
Publication date 2014-03-28
ISSN 1872-7980
Keyword(s) Aptamers
Cancer stem cells
Chemoresistance
Clonal evolution
Stemness
Science & Technology
Life Sciences & Biomedicine
Oncology
BREAST-CANCER
COLON-CANCER
DRUG-RESISTANCE
TUMOR-GROWTH
PROSPECTIVE IDENTIFICATION
MYELOID-LEUKEMIA
INITIATING CELLS
MARKER CD133
SOLID TUMORS
Summary Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.
Language eng
DOI 10.1016/j.canlet.2013.11.012
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier Ireland
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067325

Document type: Journal Article
Collections: School of Medicine
Molecular and Medical Research
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Created: Tue, 09 Dec 2014, 11:57:31 EST

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