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Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells.

Li, YC, He, SM, He, ZX, Li, M, Yang, Y, Pang, JX, Zhang, X, Chow, K, Zhou, Q, Duan, W, Zhou, ZW, Yang, T, Huang, GH, Liu, A, Qiu, JX, Liu, JP and Zhou, SF 2014, Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells., Cancer Letters, vol. 344, no. 2, pp. 239-259, doi: 10.1016/j.canlet.2013.11.001.

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Title Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells.
Author(s) Li, YC
He, SM
He, ZX
Li, M
Yang, Y
Pang, JX
Zhang, X
Chow, K
Zhou, Q
Duan, W
Zhou, ZW
Yang, T
Huang, GH
Liu, A
Qiu, JX
Liu, JP
Zhou, SF
Journal name Cancer Letters
Volume number 344
Issue number 2
Start page 239
End page 259
Total pages 21
Publisher Elsevier Ireland
Place of publication Shannon, County Clare, Ireland
Publication date 2014-03
ISSN 1872-7980
Keyword(s) Apoptosis
Autophagy
Non-small-cell lung cancer
PI3K/Akt/mTOR
Plumbagin
Science & Technology
Life Sciences & Biomedicine
Oncology
NF-KAPPA-B
CYTOCHROME-C
CYCLE ARREST
IN-VITRO
SIGNALING PATHWAY
BONE METASTASIS
P53
BREAST
PHOSPHORYLATION
EXPRESSION
Summary Plumbagin (PLB) has shown anti-cancer activity but the mechanism is unclear. This study has found that PLB has a potent pro-apoptotic and pro-autophagic effect on A549 and H23 cells. PLB arrests cells in G2/M phase, and increases the intracellular level of reactive oxygen species in both cell lines. PLB dose-dependently induces autophagy through inhibition of PI3K/Akt/mTOR pathway as indicated by reduced phosphorylation of Akt and mTOR. Inhibition or induction of autophagy enhances PLB-induced apoptosis. There is crosstalk between PLB-induced apoptosis and autophagy. These findings indicate that PLB initiates both apoptosis and autophagy in NSCLC cells through coordinated pathways.
Language eng
DOI 10.1016/j.canlet.2013.11.001
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067326

Document type: Journal Article
Collection: School of Medicine
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