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ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish

Rasighaemi, Parisa, Onnebo, Sara M., Liongue, Clifford and Ward, Alister C. 2015, ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish, Haematologica, vol. 100, no. 1, pp. 23-31, doi: 10.3324/haematol.2014.104091.

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Title ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish
Author(s) Rasighaemi, Parisa
Onnebo, Sara M.
Liongue, Clifford
Ward, Alister C.ORCID iD for Ward, Alister C. orcid.org/0000-0001-7945-7975
Journal name Haematologica
Volume number 100
Issue number 1
Start page 23
End page 31
Publisher Fondazione Ferrata Storti
Place of publication Pavia, Italy
Publication date 2015-01
ISSN 0390-6078
1592-8721
Keyword(s) ETV6
Granulocytes, Monocytes, Macrophages
Hematopoiesis
Hematopoietic Stem Cell
Red Cells
Summary Chromosomal translocations involving fusions of the human ETV6 (TEL1) gene occur frequently in hematologic malignancies. However, a detailed understanding of the normal function of ETV6 remains incomplete. This study has employed zebrafish as a relevant model to investigate the role of ETV6 during embryonic hematopoiesis. Zebrafish possessed a single conserved etv6 ortholog that was expressed from 12 hpf in the lateral plate mesoderm, and later in hematopoietic, vascular and other tissues. Morpholino-mediated gene knockdown of etv6 revealed the complex contribution of this gene toward embryonic hematopoiesis. During primitive hematopoiesis, etv6 knockdown resulted in reduced levels of progenitor cells, erythrocyte and macrophage populations, but increased numbers of incompletely differentiated heterophils. Definitive hematopoiesis was also perturbed, with etv6 knockdown leading to decreased erythrocytes and myeloid cells, but enhanced lymphopoiesis. This study suggests that ETV6 plays a broader and more complex role in early hematopoiesis than previously thought, impacting on the development of multiple lineages. © 2015 Ferrata Storti Foundation.
Language eng
DOI 10.3324/haematol.2014.104091
Field of Research 110202 Haematology
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Ferrata Storti Foundation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067344

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
Molecular and Medical Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.