Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy Liongue, Clifford and Ward, Alister Curtis 2014, Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy, Frontiers in oncology, vol. 4, Article no. 93, pp. 1-7, doi: 10.3389/fonc.2014.00093. Attached Files Name Description MIMEType Size Downloads liongue-granulocytecolony-2014.pdf Published version application/pdf 1.01MB 293 Title Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy Author(s) Liongue, Clifford orcid.org/0000-0002-1646-4905 Ward, Alister Curtis orcid.org/0000-0001-7945-7975 Journal name Frontiers in oncology Volume number 4 Season Article no. 93 Start page 1 End page 7 Total pages 7 Publisher Frontiers Research Foundation Place of publication Lausanne, Switzerland Publication date 2014-05-01 ISSN 2234-943X Keyword(s) AML CNL CSF3R G-CSF G-CSFR MDS SCN Summary Granulocyte colony-stimulating factor is a cytokine able to stimulate both myelopoiesis and hematopoietic stem cell mobilization, which has seen it used extensively in the clinic to aid hematopoietic recovery. It acts specifically via the homodimeric granulocyte colony-stimulating factor receptor (G-CSFR), which is principally expressed on the surface of myeloid and hematopoietic progenitor cells. A number of pathogenic mutations have now been identified in CSF3R, the gene encoding G-CSFR. These fall into distinct classes, each of which is associated with a particular spectrum of myeloid disorders, including malignancy. This review details the various CSF3R mutations, their mechanisms of action, and contribution to disease, as well as discussing the clinical implications of such mutations. Language eng DOI 10.3389/fonc.2014.00093 Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified Socio Economic Objective 920102 Cancer and Related Disorders HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2014, Frontiers Research Foundation Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30067370 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges   Author URL Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 13 Nov 2014, 12:30:32 EST Tue, 09 Dec 2014, 09:57:58 EST Tue, 09 Dec 2014, 13:22:46 EST Tue, 09 Dec 2014, 13:44:01 EST Tue, 16 Dec 2014, 07:44:25 EST Tue, 16 Dec 2014, 07:47:15 EST Wed, 17 Dec 2014, 09:19:48 EST Wed, 07 Sep 2016, 07:56:29 EST Wed, 06 Dec 2017, 06:10:43 EST Fri, 07 Sep 2018, 17:20:49 EST Sat, 22 Aug 2020, 02:39:06 EST Filtered Full Citation counts:   Cited 13 times in TR Web of Science Cited 16 times in Scopus Search Google Scholar Access Statistics: 604 Abstract Views, 294 File Downloads  -  Detailed Statistics Created: Tue, 09 Dec 2014, 09:57:58 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.