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Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy

Liongue, Clifford and Ward, Alister Curtis 2014, Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy, Frontiers in oncology, vol. 4, Article no. 93, pp. 1-7, doi: 10.3389/fonc.2014.00093.

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Title Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy
Author(s) Liongue, CliffordORCID iD for Liongue, Clifford orcid.org/0000-0002-1646-4905
Ward, Alister CurtisORCID iD for Ward, Alister Curtis orcid.org/0000-0001-7945-7975
Journal name Frontiers in oncology
Volume number 4
Season Article no. 93
Start page 1
End page 7
Total pages 7
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2014-05-01
ISSN 2234-943X
Keyword(s) AML
CNL
CSF3R
G-CSF
G-CSFR
MDS
SCN
Summary Granulocyte colony-stimulating factor is a cytokine able to stimulate both myelopoiesis and hematopoietic stem cell mobilization, which has seen it used extensively in the clinic to aid hematopoietic recovery. It acts specifically via the homodimeric granulocyte colony-stimulating factor receptor (G-CSFR), which is principally expressed on the surface of myeloid and hematopoietic progenitor cells. A number of pathogenic mutations have now been identified in CSF3R, the gene encoding G-CSFR. These fall into distinct classes, each of which is associated with a particular spectrum of myeloid disorders, including malignancy. This review details the various CSF3R mutations, their mechanisms of action, and contribution to disease, as well as discussing the clinical implications of such mutations.
Language eng
DOI 10.3389/fonc.2014.00093
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Frontiers Research Foundation
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067370

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.