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Novel mechanism of Col10a1 nonsense-mediated mRNA decay

Fang, Yiwen 2014, Novel mechanism of Col10a1 nonsense-mediated mRNA decay, PhD thesis, School of Life and Environmental Sciences, Deakin University.

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Title Novel mechanism of Col10a1 nonsense-mediated mRNA decay
Author Fang, Yiwen
Institution Deakin University
School School of Life and Environmental Sciences
Faculty Faculty of Science, Engineering and Built Environment
Degree type Research doctorate
Degree name PhD
Thesis advisor Bateman, John
Lamandè, Shireen
Date submitted 2014-02
Keyword(s) Nonsense-mediated mRNA decay (NMD)
DNA repair
Summary Nonsense-mediated mRNA decay (NMD) is a conserved surveillance mechanism that selectively targets mRNA transcripts carrying premature termination codons (PTCs) for rapid degradation in all studied eukaryotes. Mutations that introduce PTCs account for approximately one-third of all inherited genetic disorders, highlighting the importance of NMD in the molecular pathology of many diseases.
The experimental findings presented in this thesis demonstrate that the mechanism of Col10a1 NMD is different to previously described NMD pathways and could represent a failsafe NMD mechanism used by genes that have similar gene structures to COL10A1, which would escape the canonical NMD pathway.
Language eng
Field of Research 110105 Medical Biochemistry: Nucleic Acids
110311 Medical Genetics (excl Cancer Genetics)
060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
Description of original xvi, 271 pages : illustrations, diagrams, tables, graphs, some coloured
Copyright notice ©The author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30067414

Document type: Thesis
Collections: Higher degree theses (full text)
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Created: Fri, 14 Nov 2014, 10:29:58 EST by fez

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.